Complements and the Wound Healing Cascade: An Updated Review
Open Access
- 24 July 2013
- journal article
- review article
- Published by Hindawi Limited in Plastic Surgery International
- Vol. 2013, 1-7
- https://doi.org/10.1155/2013/146764
Abstract
Wound healing is a complex pathway of regulated reactions and cellular infiltrates. The mechanisms at play have been thoroughly studied but there is much still to learn. The health care system in the USA alone spends on average 9 billion dollars annually on treating of wounds. To help reduce patient morbidity and mortality related to abnormal or prolonged skin healing, an updated review and understanding of wound healing is essential. Recent works have helped shape the multistep process in wound healing and introduced various growth factors that can augment this process. The complement cascade has been shown to have a role in inflammation and has only recently been shown to augment wound healing. In this review, we have outlined the biology of wound healing and discussed the use of growth factors and the role of complements in this intricate pathway.Keywords
This publication has 38 references indexed in Scilit:
- Complements C3 and C5 Individually and in Combination Increase Early Wound Strength in a Rat Model of Experimental Wound HealingPlastic Surgery International, 2013
- Topical application of the tumour necrosis factor‐α antibody infliximab improves healing of chronic woundsInternational Wound Journal, 2006
- Topical Vascular Endothelial Growth Factor Accelerates Diabetic Wound Healing through Increased Angiogenesis and by Mobilizing and Recruiting Bone Marrow-Derived CellsThe American Journal of Pathology, 2004
- Novel antisense oligonucleotides targeting TGF-β inhibit in vivo scarring and improve surgical outcomeGene Therapy, 2003
- Synthetic TGF‐β antagonist accelerates wound healing and reduces scarringThe FASEB Journal, 2002
- C5a-induced expression of P-selectin in endothelial cells.JCI Insight, 1994
- Collectins: collagenous C-type lectins of the innate immune defense systemImmunology Today, 1994
- Binding specificity and presynaptic action of anaphylatoxin C5a in rat brainBrain, Behavior, and Immunity, 1989
- Accelerated Healing of Incisional Wounds in Rats Induced by Transforming Growth Factor-βScience, 1987
- The Healing of Rat Skin WoundsAnnals of Surgery, 1965