Continuous manufacturing – the Green Chemistry promise?
Open Access
- 21 May 2019
- journal article
- review article
- Published by Royal Society of Chemistry (RSC) in Green Chemistry
- Vol. 21 (13), 3481-3498
- https://doi.org/10.1039/c9gc00773c
Abstract
Continuous manufacturing and Green Chemistry, are two promising approaches to synthesis with underutilized potential that are gaining traction by the wider pharmaceutical community. We review Green Chemistry advances resulting when transitioning to continuous manufacturing with focus on Green Chemistry elements inherent in flow chemistry and related separation processes. Case studies of continuous manufacturing represented by the F3 (Flexible, Fast, and Future) project, cGPM manufacturing at Eli Lilly, and the MIT pharmaceuticals on demand projects provide examples of Green Chemistry advances realised. Throughout the review, Green Chemistry advances are identified in terms of the pertinent principles of Green Chemistry. A count of the occurrences of the different principles of Green Chemistry reveals that the principle of prevention greatly overshadows all other principles.Keywords
Funding Information
- Defense Advanced Research Projects Agency (N66001-16-C-4005.)
This publication has 127 references indexed in Scilit:
- End-to-end continuous flow synthesis and purification of diphenhydramine hydrochloride featuring atom economy, in-line separation, and flow of molten ammonium saltsChemical Science, 2013
- Continuous-Flow Reactor-Based Enzymatic Synthesis of Phosphorylated Compounds on a Large ScaleChemistry – A European Journal, 2012
- The continuous flow Barbier reaction: an improved environmental alternative to the Grignard reaction?Green Chemistry, 2012
- Continuous flow reactors: a perspectiveGreen Chemistry, 2011
- De-emulsification of Kerosene/Water Emulsions with Plate-Type MicrochannelsIndustrial & Engineering Chemistry Research, 2010
- Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin ManufactureScience, 2010
- Green chemistry for chemical synthesisProceedings of the National Academy of Sciences of the United States of America, 2008
- From form to function: Crystallization of active pharmaceutical ingredientsAIChE Journal, 2008
- Micro-scale liquid–liquid separation in a plate-type coalescerChemical Engineering and Processing - Process Intensification, 2007
- The price of innovation: new estimates of drug development costsJournal of Health Economics, 2003