Epidemiology of Hepatitis A Virus Infections, Germany, 2007–2008
Open Access
- 1 November 2009
- journal article
- Published by Centers for Disease Control and Prevention (CDC) in Emerging Infectious Diseases
- Vol. 15 (11), 1760-1768
- https://doi.org/10.3201/eid1511.090214
Abstract
Approximately 60% of hepatitis A virus infections in Germany occur in persons without a travel history to disease-endemic areas and for whom sources of infection are unknown. Recommendation of pretravel vaccination fails to prevent the remaining imported infections. Using enhanced surveillance in 2007-2008, we analyzed epidemiologic patterns of hepatitis A in Germany and appropriateness and adequacy of current immunization recommendations. Young patients with a migration background who had visited friends and family in their ancestral countries accounted for most imported cases. Phylogenetic analysis showed high diversity of sequence data and clustering of strains with similar regions of origin or patient migration backgrounds. Virologic findings are compatible with those of low-incidence countries, where virtually all infections are directly or indirectly imported from other regions. Germans with a migration background are seen as a special risk group so far insufficiently reached by pretravel vaccination advice.Keywords
This publication has 20 references indexed in Scilit:
- Hepatitis A among Danish travellers 1980–2007Journal of Infection, 2009
- Differences in hepatitis A seroprevalence among geographical regions in Turkey: a need for regional vaccination recommendationsJournal of Viral Hepatitis, 2008
- MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) Software Version 4.0Molecular Biology and Evolution, 2007
- Pretravel Advice and Hepatitis A Immunization Among Australian TravelersJournal of Travel Medicine, 2007
- Hepatitis A Virus Infections in Travelers, 1988-2004Clinical Infectious Diseases, 2006
- Diagnosis of Hepatitis A Virus Infection: a Molecular ApproachClinical Microbiology Reviews, 2006
- Health Disparities among Travelers Visiting Friends and Relatives AbroadAnnals of Internal Medicine, 2005
- Knowledge, Attitudes and Practices in Travel-related Infectious Diseases: The European Airport SurveyJournal of Travel Medicine, 2004
- Prevalence of markers for hepatitis A, B and C in the German population. Results of the German National Health Interview and Examination Survey 1998.European Journal of Epidemiology, 2001
- CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceNucleic Acids Research, 1994