Supplementary Tables includes 8 tables. Supplementary Table S1: Patient-derived cancer cells: Patient and model characteristics. Supplementary Table S2: List of primer sequences used in quantitative RT-PCR for gene expression analysis. Supplementary Table S3: List of primer sequences used in quantitative PCR for DNA copy number determination. Supplementary Table S4: The list of pathways detected by the protein array and their calculated value scores. Supplementary Table S5: The combination of osimertinib and linsitinib demonstrated a synergistic anti-proliferative effect in PC9AZDR cells. Supplementary Table S6: Mutations detected by target sequence in KOLK43 cells. Supplementary Table S7: The combination of osimertinib and linsitinib demonstrated synergistic anti-proliferative effect in KOLK43 cells. Supplementary Table S8: IGF2 is upregulated in human EGFR-mutant NSCLC with resistance to EGFR-TKI.