A single standard nocturnal dose of nizatidine enhances the healing of active duodenal ulcers among Chinese
- 1 April 1995
- journal article
- clinical trial
- Published by Wiley in Journal of Gastroenterology and Hepatology
- Vol. 10 (2), 135-139
- https://doi.org/10.1111/j.1440-1746.1995.tb01067.x
Abstract
Chinese people have a lower maximal acid output and gastrin response to meals compared to Western people. The aim of the present study was to assess the efficacy of a half-single nocturnal dose of nizatidine (150 mg at bedtime [h.s.], n = 40) with a standard full dose given once nightly (300 mg h.s., n = 38) or twice daily (150 mg twice a day [b.i.d.], n = 43) in the treatment of Chinese patients with active duodenal ulcers. An endoscopy was performed upon entry and at 4 week intervals until the ulcer healed (up to 8 weeks). There is no statistical difference in healing rates after 4 weeks of treatment (52.5, 52 and 47% in nizatidine 150 mg h.s., 150 mg b.i.d. and nizatidine 300 mg h.s., respectively) whereas nizatidine 300 h.s. had a significantly higher healing rate compared to nizatidine 150 mg h.s. and b.i.d. after 8 weeks of treatment (89 vs 70 and 67%, P < 0.05) by uni- and multivariate analysis of clinical and endoscopic characteristics. Symptomatic response was not significantly different in these three treated groups. Our study suggested that a half-single nocturnal dose of nizatidine is not ideal for the treatment of duodenal ulcer in Chinese patients, whereas a single standard nocturnal dose appears more effective than a twice-daily regimen.Keywords
This publication has 14 references indexed in Scilit:
- A comparative study of once-a-day morning and once-a-day bedtime administration of 40 mg famotidine in treating duodenal ulcersGastroenterologia Japonica, 1992
- Low-dose cimetidine in the acute treatment of duodenal ulcer. Comparison of a single nocturnal dose regimen with a twice daily regimenJournal of Gastroenterology and Hepatology, 1990
- Comparison of ranitidine 300 mg twice daily, 300 mg at night and placebo on 24‐hour intragastric acidity of duodenal ulcer patientsAlimentary Pharmacology & Therapeutics, 1987
- 300 Mg Nizatidine at Night versus 300 Mg Ranitidine at Night in Patients with Duodenal Ulcer: A Multicentre Trial in EuropeScandinavian Journal of Gastroenterology, 1987
- Treatment of Duodenal Ulceration in the United StatesScandinavian Journal of Gastroenterology, 1987
- Pharmacodynamics of famotidine in humansAmerican Journal Of Medicine, 1986
- Nocturnal Gastric Acid Secretion: Its Importance in the Pathophysiology and Rational Therapy of Duodenal UlcerScandinavian Journal of Gastroenterology, 1986
- Controlled therapeutic trial to determine the optimum dose of antacids in duodenal ulcer.Gut, 1984
- Comparison of maximal acid output and gastrin response to meals in Chinese and Scottish normal and duodenal ulcer subjects.Gut, 1980