Gilbert??s Syndrome and Drug Metabolism
- 1 January 1979
- journal article
- review article
- Published by Springer Science and Business Media LLC in Clinical Pharmacokinetics
- Vol. 4 (3), 223-232
- https://doi.org/10.2165/00003088-197904030-00004
Abstract
Gilbert’s syndrome is an inherited disorder which is characterised by unconjugated hyper-bilirubinaemia. In patients with Gilbert’s syndrome, both bilirubin clearance and in vitro hepatic microsomal uridine diphosphoglucuronyl transferase (UDPGT) activity are reduced. In addition, there is evidence suggesting impaired hepatic uptake of bilirubin in Gilbert’s syndrome. Glucuronidation of a number of substrates appears to be impaired in Gilbert’s syndrome, but the significance of the reported changes in oxidation and acetylation are less clear.This publication has 44 references indexed in Scilit:
- Definition of a Conjugation Dysfunction in Gilbert's Syndrome: Studies of the Handling of Bilirubin Loads and of the Pattern of Bilirubin Conjugates Secreted in BileClinical Science, 1978
- Hepatic Accumulation and Intracellular Binding of Conjugated BilirubinJCI Insight, 1978
- [The genetics of Gilbert syndrome].1976
- Population studies on Gilbert's syndrome.Journal of Medical Genetics, 1975
- Reduced caloric intake and nicontinic acid provocation tests in the diagnosis of Gilbert's syndrome.BMJ, 1975
- Liver ultrastructure in Gilbert's syndrome.Gut, 1975
- Effects of Caloric and Noncaloric Materials in Fasting HyperbilirubinemiaGastroenterology, 1975
- Two hepatic cytoplasmic protein fractions, Y and Z, and their possible role in the hepatic uptake of bilirubin, sulfobromophthalein, and other anionsJCI Insight, 1969
- AN ASSESSMENT OF RED CELL SURVIVAL IN IDIOPATHIC UNCONJUGATED HYPERBILIRUBINÆMIA (GILBERT'S SYNDROME) BY THE USE OF RADIOACTIVE DIISOPROPYLFLUOROPHOSPHATE AND CHROMIUMAustralasian Annals of Medicine, 1967
- DEFECTS IN HEPATIC TRANSPORT OF BILIRUBIN IN CONGENITAL HYPERBILIRUBINAEMIA - ANALYSIS OF PLASMA BILIRUBIN DISAPPEARANCE CURVES1964