Mechanisms of metastasis
Open Access
- 1 February 2008
- journal article
- review article
- Published by Springer Science and Business Media LLC in Breast Cancer Research
- Vol. 10 (S1), S2
- https://doi.org/10.1186/bcr1988
Abstract
Metastasis is an enormously complex process that remains to be a major problem in the management of cancer. The fact that cancer patients might develop metastasis after years or even decades from diagnosis of the primary tumor makes the metastatic process even more complex. Over the years many hypotheses were developed to try to explain the inefficiency of the metastatic process, but none of these theories completely explains the current biological and clinical observations. In this review we summarize some of the proposed models that were developed in attempt to understand the mechanisms of tumor dissemination and colonization as well as metastatic progression.Keywords
This publication has 93 references indexed in Scilit:
- Metastasis Predictive Signature Profiles Pre-exist in Normal TissuesClinical & Experimental Metastasis, 2005
- A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast CancerThe New England Journal of Medicine, 2004
- Gene Expression Signature of Fibroblast Serum Response Predicts Human Cancer Progression: Similarities between Tumors and WoundsPLoS Biology, 2004
- Tumour-educated macrophages promote tumour progression and metastasisNature Reviews Cancer, 2004
- A molecular signature of metastasis in primary solid tumorsNature Genetics, 2002
- Metastasis genes: A progression puzzleNature, 2002
- Gene expression profiling predicts clinical outcome of breast cancerNature, 2002
- Multistep Nature of Metastatic Inefficiency: Dormancy of Solitary Cells after Successful Extravasation and Limited Survival of Early MicrometastasesThe American Journal of Pathology, 1998
- Circulating DNA as a Possible Factor in OncogenesisScience, 1965
- THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST.The Lancet, 1889