Probiotics Lactobacillus reuteri DSM 17938 and Lactobacillus casei CRL 431 Modestly Increase Growth, but Not Iron and Zinc Status, among Indonesian Children Aged 1–6 Years1–4
Open Access
- 1 July 2013
- journal article
- research article
- Published by Elsevier BV in Journal of Nutrition
- Vol. 143 (7), 1184-1193
- https://doi.org/10.3945/jn.112.166397
Abstract
Probiotics and milk calcium may increase resistance to intestinal infection, but their effect on growth and iron and zinc status of Indonesian children is uncertain. We investigated the hypotheses that cow milk with added probiotics would improve growth and iron and zinc status of Indonesian children, whereas milk calcium alone would improve growth but reduce iron and zinc status. A 6-mo randomized trial was conducted in low-socioeconomic urban communities of Jakarta. Healthy children (n = 494) were randomly assigned to receive low-lactose milk with a low calcium content of ∼50 mg/d (LC; n = 124), a regular calcium content of ∼440 mg/d (RC group; n = 126), regular calcium with 5 × 108 CFU/d Lactobacillus casei CRL 431 (casei; n = 120), or regular calcium with 5 × 108 CFU/d Lactobacillus reuteri DSM 17938 (reuteri; n = 124). Growth, anemia, and iron and zinc status were assessed before and after the intervention. Compared with the RC group, the reuteri group had significantly greater weight gain [0.22 (95% CI: 0.02, 0.42) kg], weight-for-age Z-score (WAZ) changes [0.09 (95% CI: 0.01, 0.17)], and monthly weight [0.03 (95% CI: 0.002, 0.05) kg/mo] and height [0.03 (95% CI: 0.01, 0.05) cm/mo] velocities. Casei significantly increased monthly weight velocity [0.03 (95% CI: 0.001, 0.05) kg/mo], but not height. However, the changes in underweight, stunting, anemia prevalence, and iron and zinc status were similar between groups. In conclusion, L. reuteri DSM 17938 modestly improved growth by increasing weight gain, WAZ changes, and weight and height velocity, whereas L. casei CRL 431 modestly improved weight velocity. Independent from probiotics supplementation, regular milk calcium did not affect growth or iron and zinc status.Keywords
This publication has 62 references indexed in Scilit:
- The Effect of Adding Ready-to-Use Supplementary Food to a General Food Distribution on Child Nutritional Status and Morbidity: A Cluster-Randomized Controlled TrialPLoS Medicine, 2012
- Multisector intervention to accelerate reductions in child stunting: an observational study from 9 sub-Saharan African countriesThe American Journal of Clinical Nutrition, 2011
- Micronutrient Fortified Milk Improves Iron Status, Anemia and Growth among Children 1–4 Years: A Double Masked, Randomized, Controlled TrialPLOS ONE, 2010
- Anti-infective mechanisms induced by a probiotic Lactobacillus strain against Salmonella enterica serovar Typhimurium infectionInternational Journal of Food Microbiology, 2010
- Probiotics: progress toward novel therapies for intestinal diseasesCurrent Opinion in Gastroenterology, 2010
- Cow's milk protein allergy in children: a practical guideItalian Journal of Pediatrics, 2010
- Optimization of a phytase-containing micronutrient powder with low amounts of highly bioavailable iron for in-home fortification of complementary foodsThe American Journal of Clinical Nutrition, 2009
- Removal of Antibiotic Resistance Gene-Carrying Plasmids from Lactobacillus reuteri ATCC 55730 and Characterization of the Resulting Daughter Strain, L . reuteri DSM 17938Applied and Environmental Microbiology, 2008
- Maternal and child undernutrition: global and regional exposures and health consequencesThe Lancet, 2008
- Probiotic Escherichia coli Nissle 1917 Inhibits Leaky Gut by Enhancing Mucosal IntegrityPLOS ONE, 2007