A qPCR‐based metric of Th2 airway inflammation in asthma
Open Access
- 1 January 2013
- journal article
- Published by Wiley in Clinical and Translational Allergy
- Vol. 3 (1), 24
- https://doi.org/10.1186/2045-7022-3-24
Abstract
Using microarray profiling of airway epithelial cells, we previously identified a Th2-high molecular phenotype of asthma based on expression of periostin, CLCA1 and serpinB2 and characterized by specific inflammatory, remodeling, and treatment response features. The goal of the current study was to develop a qPCR-based assay of Th2 inflammation to overcome the limitations of microarray-based methods.Keywords
This publication has 27 references indexed in Scilit:
- Mepolizumab for severe eosinophilic asthma (DREAM): a multicentre, double-blind, placebo-controlled trialThe Lancet, 2012
- Human asthma phenotypes: from the clinic, to cytokines, and back againImmunological Reviews, 2011
- Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard TherapyAnnals of Internal Medicine, 2011
- Gene Expression Patterns of Th2 Inflammation and Intercellular Communication in Asthmatic AirwaysThe Journal of Immunology, 2011
- Mepolizumab and Exacerbations of Refractory Eosinophilic AsthmaThe New England Journal of Medicine, 2009
- Mepolizumab for Prednisone-Dependent Asthma with Sputum EosinophiliaThe New England Journal of Medicine, 2009
- Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroidsProceedings of the National Academy of Sciences of the United States of America, 2007
- The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trialJournal of Allergy and Clinical Immunology, 2007
- Can Guideline-defined Asthma Control Be Achieved?American Journal of Respiratory and Critical Care Medicine, 2004
- Significant variability in response to inhaled corticosteroids for persistent asthmaJournal of Allergy and Clinical Immunology, 2002