Detection of a mediator derived from endotoxin-stimulated macrohpages that induces the acute phase serum amyloid A response in mice.
Open Access
- 1 September 1979
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 150 (3), 597-606
- https://doi.org/10.1084/jem.150.3.597
Abstract
The mechanism by which LPS stimulates an acute phase serum amyloid A (SAA) response in C3H mice has been studied. A factor (SAA inducer) appears in the blood of C3H/HeN (lipopolysaccharide [LPS]-sensitive) mice approximately 1 h after administration of LPS, which, when passively administered, can induce C3H/HeJ mice to produce SAA although they are resistant to the LPS itself. SAA inducer has been detected in the culture medium of LPS treated C3H/HeN macrophages but not spleen cells. Thus, two stages in the induction of the acute phase SAA response are now recognized: a latent period of 2-3 h during which the SAA concentration remains at baseline values and in which SAA inducer appears, and the period of synthesis of SAA which lasts for approoximately 24 h past induction. It is proposed that a macrophage response to LPS is responsible for production of the serum mediator which induces SAA synthesis.Keywords
This publication has 22 references indexed in Scilit:
- The Effect of Glucocorticoid Antagonizing Factor on Hepatoma CellsExperimental Biology and Medicine, 1978
- Degradation of serum amyloid A protein by surface-associated enzymes of human blood monocytes.The Journal of Experimental Medicine, 1978
- Control of the acute phase response. Demonstration of C-reactive protein synthesis and secretion by hepatocytes during acute inflammation in the rabbit.The Journal of Experimental Medicine, 1978
- Changes in Human Serum Amyloid A and C-Reactive Protein after Etiocholanolone-Induced InflammationJCI Insight, 1978
- Localization of amyloid-related serum protein SAA-like material to intermediate (10 nm) filaments of cultured human embryonal fibroblasts.The Journal of Experimental Medicine, 1977
- IMMUNOCHEMICAL STUDIES ON NATURE OF SERUM COMPONENT (SAA) RELATED TO SECONDARY AMYLOIDOSIS1977
- Amyloid-Related Serum Protein SAA from Three Animal Species: Comparison with Human SAAThe Journal of Immunology, 1976
- Isolation of a low-molecular-weight serum component antigenically related to an amyloid fibril protein of unknown origin.Proceedings of the National Academy of Sciences of the United States of America, 1975
- Variation with age and disease of an amyloid A protein-related serum component.JCI Insight, 1975
- Murine Amyloidosis: Immunologic Characterization of Amyloid Fibril ProteinThe Journal of Immunology, 1971