Novel Regiospecific Method for Synthesis of 2‐(3,5‐Diaryl‐4,5‐dihydro‐1H‐pyrazol‐1‐yl)‐4,6‐diarylpyrimidines
- 1 February 2008
- journal article
- research article
- Published by Informa UK Limited in Synthetic Communications
- Vol. 38 (6), 943-952
- https://doi.org/10.1080/00397910701845555
Abstract
The facile, regiospecific, one‐pot synthesis of 2‐(3,5‐diaryl‐4,5‐dihydro‐1H‐pyrazol‐1‐yl)‐4,6‐diarylpyrimidines derivatives has been described, involving a [3+2] and [3+3] cyclocondensation between the α,β‐unsaturated ketones and aminoguanidine bicarbonate.Keywords
This publication has 12 references indexed in Scilit:
- Synthesis of New 2-(5-Aryl-3-styryl-4,5-dihydro-1H-pyrazol-1-yl)-4-(trifluoromethyl)pyrimidinesSynthesis, 2006
- Synthesis of Alkyl-, Aryl- and Heteroaryl-Substituted 2-[3-Oxo-2,3-dihydro-1H-pyrazol-2-yl]-6(4)-trifluoromethylpyrimidines from β-Alkoxyvinyl Trifluoromethyl KetonesSynthesis, 2005
- Regiospecific Cyclization of4-Alkoxyvinyl Trifluoro[chloro]methyl Ketones with6-Trifluoro[chloro]methyl-2-hydrazine Pyrimidines.A Convenient Method to Obtain Trifluoro[chloro]methylated2-(5-Hydroxy-5-trifluoro[chloro]methyl-4,5-dihydro-1H-Pyrazol-l-yl]-pyrimidinesSynthesis, 2003
- A NEW SOLVENT-FREE SYNTHESIS OF α,β-UNSATURATED KETONES FROM ACETALS WITH ARYL KETONES UNDER MICROWAVE IRRADIATIONSynthetic Communications, 2002
- Regiospecific Cyclization of β-Methoxyvinyl Trifluoromethyl Ketones with Aminoguanidine: A Convenient Method to Obtain Trifluoromethylated 2-[1H-Pyrazol-1-yl]pyrimidinesSynthesis, 2001
- Convenient Synthesis of α,α1-bis(Substituted Furfurylidene) Cycloalkanones and Chalcones Under Microwave Irradiation.Synthetic Communications, 1997
- Synthesis andin vitroevaluation of some new pyrimidines and related condensed ring systems as potential anticancer agentsJournal of Heterocyclic Chemistry, 1996
- Synthesis and Cytoprotective Antiulcer Activity of 2- or 4-(lH-Pyrazol-1-yl)pyrimidine Derivatives Related to Mepirizole and Dulcerozine.CHEMICAL & PHARMACEUTICAL BULLETIN, 1996
- Studies on Pyrimidinylpyrazoles. IV. Pharmacological Activities of 1-(4-Methoxy-6-methyl-2-pyrimidinyl)-3-methyl-5-methoxypyrazole and Its Related CompoundsCHEMICAL & PHARMACEUTICAL BULLETIN, 1969
- Studies on Pyrimidinylpyrazoles. I. Syntheses of 1-and 2-Pyrimidinyl-3-methylpyrazolin-5-one DerivativesCHEMICAL & PHARMACEUTICAL BULLETIN, 1969