Therapeutic Targets for Neuroprotection in Acute Ischemic Stroke: Lost in Translation?
- 15 May 2011
- journal article
- review article
- Published by Mary Ann Liebert Inc in Antioxidants and Redox Signaling
- Vol. 14 (10), 1841-1851
- https://doi.org/10.1089/ars.2010.3292
Abstract
The development of a suitable neuroprotective agent to treat ischemic stroke has failed when transitioned to the clinical setting. An understanding of the molecular mechanisms involved in neuronal injury during ischemic stroke is important, but must be placed in the clinical context. Current therapeutic targets have focused on the preservation of the ischemic penumbra in the hope of improving clinical outcomes. Unfortunately, most patients in the ultra-early time windows harbor penumbra but have tremendous variability in the size of the core infarct, the ultimate predictor of prognosis. Understanding this variability may allow for proper patient selection that may better correlate to bench models. Reperfusion therapies are rapidly evolving and have been shown to improve clinical outcomes. The use of neuroprotective agents to prolong time windows prior to reperfusion or to prevent reperfusion injury may present future therapeutic targets for the treatment of ischemic stroke. We review the molecular pathways and the clinical context from which future targets may be identified. Antioxid. Redox Signal. 14, 1841–1851.Keywords
This publication has 66 references indexed in Scilit:
- Caffeinol at the Receptor LevelStroke, 2010
- Mismatch-Based Delayed ThrombolysisStroke, 2010
- The Stroke Patient Who Woke UpStroke, 2002
- Metabotropic Glutamate Receptor Subtypes as Targets for Neuroprotective DrugsJournal of Cerebral Blood Flow & Metabolism, 2001
- Cooling for Acute Ischemic Brain Damage (COOL AID)Stroke, 2001
- Anoxic Depolarization Mediates Acute Damage Independent of Glutamate in Neocortical Brain SlicesCerebral Cortex, 2001
- Perfusion Thresholds in Human Cerebral Ischemia: Historical Perspective and Therapeutic ImplicationsCerebrovascular Diseases, 2001
- Imaging Anoxic Depolarization During Ischemia-Like Conditions in the Mouse Hemi-Brain SliceJournal of Neurophysiology, 2001
- Stress management – heat shock protein-70 and the regulation of apoptosisTrends in Cell Biology, 2001
- Lubeluzole in Acute Ischemic Stroke TreatmentStroke, 2000