Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease
Top Cited Papers
Open Access
- 16 April 2018
- journal article
- review article
- Published by Hindawi Limited in Journal of Immunology Research
- Vol. 2018, 1-12
- https://doi.org/10.1155/2018/4784268
Abstract
Neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) impose a pressing burden on our developed and consequently aging society. Misfolded protein aggregates are a critical aspect of several neurodegenerative diseases. Nevertheless, several questions remain unanswered regarding the role of misfolded protein aggregates and the cause of neuronal cell death. Recently, it has been postulated that neuroinflammatory processes might play a crucial role in the pathogenesis of PD. Numerous postmortem, brain imaging, epidemiological, and animal studies have documented the involvement of the innate and adaptive immunity in neurodegeneration. Whether these inflammatory processes are directly involved in the etiology of PD or represent secondary consequences of nigrostriatal pathway injury is the subject of intensive research. Immune alterations in response to extracellular α-synuclein may play a critical role in modulating Parkinson’s disease progression. In this review, we address the current concept of neuroinflammation and its involvement in PD-associated neurodegeneration.Funding Information
- FWO Flanders
This publication has 109 references indexed in Scilit:
- CD4+ Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson’s DiseaseJournal of Neuroimmune Pharmacology, 2012
- Neurodegenerative phenotypes in an A53T -synuclein transgenic mouse model are independent of LRRK2Human Molecular Genetics, 2012
- Functional classification of class II human leukocyte antigen (HLA) molecules reveals seven different supertypes and a surprising degree of repertoire sharing across supertypesImmunogenetics, 2011
- Delayed Dominant-Negative TNF Gene Therapy Halts Progressive Loss of Nigral Dopaminergic Neurons in a Rat Model of Parkinson's DiseaseMolecular Therapy, 2011
- Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's diseaseNature Genetics, 2010
- Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic interventionNeurobiology of Disease, 2010
- Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disordersActa Neuropathologica, 2010
- Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synucleinNeuron, 2009
- Synuclein activates microglia in a model of Parkinson's diseaseNeurobiology of Aging, 2008
- Intranigral Lentiviral Delivery of Dominant-negative TNF Attenuates Neurodegeneration and Behavioral Deficits in Hemiparkinsonian ratsMolecular Therapy, 2008