Association of brachial-ankle pulse wave velocity with atherosclerosis and presence of coronary artery disease in older patients
Open Access
- 1 August 2015
- journal article
- Published by Taylor & Francis Ltd in Clinical Interventions in Aging
- Vol. ume 10, 1369-1375
- https://doi.org/10.2147/cia.s89568
Abstract
Association of brachial-ankle pulse wave velocity with atherosclerosis and presence of coronary artery disease in older patients Chang-Min Chung,1,2 Yu-Hsiang Tseng,3 Yu-Sheng Lin,3 Jen-Te Hsu,4 Po-Chang Wang31School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan County, 2Chang Gung University of Science and Technology, Chiayi County, 3Division of Cardiology, Chang Gung Memorial Hospital, Chiayi, 4Department of Medicine, College of Medicine, Chang Gung University, Taoyuan County, TaiwanObjective: Brachial-ankle pulse wave velocity (baPWV) is a simple and reproducible measure of arterial stiffness and is extensively used to assess risk of cardiovascular disease in Asia. We examined whether baPWV was associated with coronary atherosclerosis and presence and extent of coronary artery disease (CAD) in older patients with chest pain.Methods: This cross-sectional study enrolled 370 consecutive patients >65 years old who underwent baPWV measurement and elective coronary angiogram for suspected CAD at a single cardiovascular center, between June 2013 and July 2014.Results: In addition to diabetes mellitus and body mass index, baPWV was one of the statistically meaningful predictors of significant CAD (diameter of stenosis >50%) in a multivariate analysis. When the extent of CAD was classified as nonsignificant or significant CAD (ie, one-, two-, and three-vessel disease), there was a significant difference in baPWV between the significant and nonsignificant CAD groups, but not between the three significant CAD groups. Multivariate linear regression analyses showed that the number of diseased vessels and baPWV were both significantly associated with the SYNTAX (SYNergy between percutaneous coronary intervention with TAXus and cardiac surgery) score. The cutoff value of baPWV at 1,874 cm/s had a sensitivity of 60.1%, specificity of 70.8%, and area under receiver operating characteristic curve of 0.639 in predicting CAD.Conclusion: Arterial stiffness determined by baPWV was associated independently with CAD severity, as assessed by angiography and the SYNTAX score in older patients with chest pain. As a result, increased arterial stiffness assessed by baPWV is associated with the severity and presence of CAD in older patients.Keywords: brachial-ankle pulse wave velocity, arterial stiffness, coronary artery disease, SYNTAX scoreKeywords
This publication has 31 references indexed in Scilit:
- 2013 ACC/AHA Guideline on the Assessment of Cardiovascular RiskCirculation, 2014
- Prediction of Cardiovascular Events and All-Cause Mortality With Brachial-Ankle Elasticity IndexHypertension, 2012
- Association between brachial-ankle pulse wave velocity and occult coronary artery disease detected by multi-detector computed tomographyInternational Journal of Cardiology, 2012
- Brachial-ankle pulse wave velocity as a risk stratification index for the short-term prognosis of type 2 diabetic patients with coronary artery diseaseHypertension Research, 2010
- Prognostic Significance of Ankle-Brachial Index, Brachial-Ankle Pulse Wave Velocity, Flow-Mediated Dilation, and Nitroglycerin-Mediated Dilation in End-Stage Renal DiseaseAmerican Journal of Nephrology, 2009
- Elevated Arterial Stiffness Evaluated by Brachial-Ankle Pulse Wave Velocity is Deleterious for the Prognosis of Patients With Heart FailureCirculation Journal, 2009
- Metabolic syndrome and arterial stiffness: The Health 2000 SurveyMetabolism, 2007
- Impact of Brachial-Ankle Pulse Wave Velocity and Ankle-Brachial Blood Pressure Index on Mortality in Hemodialysis PatientsAmerican Journal of Kidney Diseases, 2005
- Brachial - Ankle Pulse Wave Velocity is a Simple and Independent Predictor of Prognosis in Patients With Acute Coronary SyndromeCirculation Journal, 2005
- Validity, Reproducibility, and Clinical Significance of Noninvasive Brachial-Ankle Pulse Wave Velocity Measurement.Hypertension Research, 2002