Breast Fine Needle Aspiration Biopsy Cytology Using the Newly Proposed IAC Yokohama System for Reporting Breast Cytopathology: The Experience of a Single Institution
- 15 February 2019
- journal article
- research article
- Published by S. Karger AG in Acta Cytologica
- Vol. 63 (4), 274-279
- https://doi.org/10.1159/000492638
Abstract
Objective: Recently the International Academy of Cytology (IAC) proposed a new reporting system for breast fine needle aspiration biopsy (FNAB) cytology. We aimed to categorize our samples according to this classification and to assess the risk of malignancy (ROM) for each category as well as the diagnostic yield of breast FNAB. Study Design: Breast FNAB specimens obtained between January 2007 and December 2017 were reclassified according to the newly proposed IAC Yokohama reporting system. The ROM for each category was determined. Diagnostic yield was evaluated based on a three-category approach, benign versus malignant. Results: The samples were distributed as follows: insufficient material 5.77%, benign 73.38%, atypical 13.74%, suspicious for malignancy 1.57%, and malignant 5.54%. Of the 3,625 cases collected, 776 (21.4%) had corresponding histology. The respective ROM for each category was 4.8% for category 1 (insufficient material), 1.4% for category 2 (benign), 13% for category 3 (atypical), 97.1% for category 4 (suspicious for malignancy), and 100% for category 5 (malignant). When only malignant cases were considered positive tests, the sensitivity, specificity, and diagnostic accuracy were 97.56, 100, and 99.11%, respectively. Conclusions: Our study is the first to categorize breast FNAB cytology samples according to the proposed IAC reporting system and to evaluate patient outcomes based on this categorization.Keywords
This publication has 15 references indexed in Scilit:
- A Modified Triple Test for Palpable Breast Masses: The Value of Ultrasound and Core Needle BiopsyAnnals of Surgical Oncology, 2012
- Benign Breast DiseasesClinical Obstetrics and Gynecology, 2011
- Comparison of accuracy of diagnostic modalities for evaluation of breast cancer with review of literatureDiagnostic Cytopathology, 2009
- Role of fine-needle aspiration cytology and core biopsy in the preoperative diagnosis of screen-detected breast carcinomaBritish Journal of Cancer, 2006
- Fine‐needle aspiration cytology vs. core biopsy in the diagnosis of breast lesionsDiagnostic Cytopathology, 2003
- Evidence relevant to the investigation of breast symptoms: the triple testThe Breast, 2002
- Fine-Needle Aspiration Biopsy of Nonpalpable Breast Lesions in a Multicenter Clinical Trial: Results from the Radiologic Diagnostic Oncology Group VRadiology, 2001
- A comparison of aspiration cytology and core needle biopsy in the evaluation of breast lesionsCancer, 2001
- Fine needle aspiration cytology in the UK breast screening programme: a national audit of resultsThe Breast, 1999
- Rate of insufficient samples for fine-needle aspiration for nonpalpable breast lesions in a multicenter clinical trialCancer, 1998