Is an early calcium flux necessary to stimulate lymphocytes?
- 1 June 1977
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 267 (5611), 490-494
- https://doi.org/10.1038/267490a0
Abstract
Concentrations of concanavalin A or the calcium ionophore A23187 that are optimal for the transformation of pig or mouse lymphocytes do not normally cause a measurable increase in calcium influx compared with unstimulated cells. If the cells are treated with the mitogens in conditions where a measurable increase in calcium influx occurs, no stimulation of the cells can occur while the flux is maintained. If any early influx of extracellular calcium is necessary for stimulation, then a much smaller increase in the total concentration of cellular calcium than reported previously is sufficient to allow the entry of lymphocytes into the cell cycle.This publication has 11 references indexed in Scilit:
- Calcium and lymphocyte activationCellular Immunology, 1976
- Proliferation of human peripheral blood lymphocytes induced by A23187, a streptomyces antibioticExperimental Cell Research, 1976
- Induction of increased calcium uptake in mouse T lymphocytes by concanavalin A and its modulation by cyclic nucleotidesNature, 1975
- Correlation between mitogenicity and stimulation of calcium uptake in human lymphocytesBiochemical and Biophysical Research Communications, 1974
- The role of calcium ions in initiating transformation of lymphocytesNature, 1974
- A rapid technique for separation of thymocytes from suspensions by centrifugation through silicone oilAnalytical Biochemistry, 1974
- Characteristics of calcium accumulation by lymphocytes and alterations in the process induced by phytohemagglutininJournal of Cellular Physiology, 1973
- Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytesExperimental Cell Research, 1973
- Enhanced uptake of calcium by transforming lymphocytesCellular Immunology, 1972
- Control of protein synthesis during the activation of lymphocytes by phytohaemagglutininBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1971