Pneumococcal bacteremia during a decade in children in Soweto, South Africa
- 1 May 2000
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in The Pediatric Infectious Disease Journal
- Vol. 19 (5), 454-457
- https://doi.org/10.1097/00006454-200005000-00012
Abstract
To monitor for a decade the incidence and the clinical and microbiologic characteristics of pneumococcal bacteremia in children in Soweto and to assess the influence of HIV infection on any changes. Case records of children with pneumococcal bacteremia at Chris Hani Baragwanath Hospital from July, 1986, to June, 1987 (1986/1987), and from July, 1996, to June, 1997 (1996/1997), were retrospectively reviewed. There were 194 episodes, 62 in 1986/1987 and 132 in 1996/1997. The minimum annual incidence for children younger than 5 years of age increased from 61 per 100 000 (179 per 100 000 for those <12 months old) in 1986/1987 to 130 per 100 000 (349 per 100 000 for those <12 months old) in 1996/1997. Sixty-seven (60%) of 111 patients tested in 1996/1997 were HIV-seropositive; none were tested in 1986/1987. The HIV-infected compared with HIV-noninfected were more likely to be malnourished (61% vs. 36%, P = 0.02), less likely to have other underlying disease (12% vs. 50%, P = 0.00001) and more frequently used antibiotics recently (69% vs. 43%, P = 0,008). Penicillin-nonsusceptible isolates were found in 22 (35%) patients in 1986/1987 and 52 (39%) in 1996/1997. There was no significant change in antimicrobial susceptibility during the decade or by HIV serostatus. Children in Soweto had a high incidence of pneumococcal bacteremia which doubled during the decade mainly as a result of the impact of the HIV epidemic. There has been no significant change in antimicrobial susceptibility for the decade.Keywords
This publication has 27 references indexed in Scilit:
- Community-acquired Bacteremia in Human Immunodeficiency Virus-infected Children in Harare, ZimbabweThe Pediatric Infectious Disease Journal, 1996
- Epidemiology and in vitro susceptibility of drug-resistant Streptococcus pneumoniaeThe Pediatric Infectious Disease Journal, 1996
- Pilot trial of a pentavalent pneumococcal polysaccharide/protein conjugate vaccine in Gambian infantsThe Pediatric Infectious Disease Journal, 1996
- Risk Factors for Isolation of Streptococcus pneumoniae with Decreased Susceptibility to Penicillin G from Patients Infected with Human Immunodeficiency VirusClinical Infectious Diseases, 1996
- Invasive pneumococcal disease in a pediatric population, Auckland, New ZealandThe Pediatric Infectious Disease Journal, 1994
- Streptococcus pneumoniae in human immunodeficiency virus type 1-infected childrenThe Pediatric Infectious Disease Journal, 1994
- Invasive pneumococcal disease among infected and uninfected children of mothers with human immunodeficiency virus infectionThe Journal of Pediatrics, 1994
- High incidence rates of invasive pneumococcal disease in the White Mountain Apache populationArchives of Internal Medicine, 1992
- Invasive pneumococcal disease in an Alaska native population, 1980 through 1986Jama-Journal Of The American Medical Association, 1989
- Emergence of Multiply Resistant PneumococciNew England Journal of Medicine, 1978