Dexamethasone enhanced by insulin, but not by thyroid hormones stimulates apolipoprotein B mRNA editing in cultured rat hepatocytes depending on the developmental stage
- 5 August 1996
- journal article
- Published by Wiley in FEBS Letters
- Vol. 391 (1-2), 57-60
- https://doi.org/10.1016/0014-5793(96)00706-5
Abstract
The increase of hepatic apolipoprotein B (apoB) mRNA editing during rat development was not affected by hypothyroidism. Furthermore, the addition of 3,3′,5-triiodothyronine (T3) to cultured hepatocytes taken from fetal, neonatal and adult rats had no effect on apoB mRNA editing. In contrast, dexamethasone markedly stimulated apoB mRNA editing in hepatocytes taken from neonates. This effect was enhanced by the addition of insulin. For the first time our data provide evidence that glucocorticoids together with insulin are important for the regulation of apoB mRNA editing during postnatal development, whereas thyroid hormones are not critical for this process.Keywords
This publication has 30 references indexed in Scilit:
- The pattern of apolipoprotein B100 containing lipoprotein subclasses produced by the isolated visceral rat yolk sac depends on developmental stage and fatty acid availabilityBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1996
- Increased apoB100 mRNA in Inbred Strains of Mice by Estrogen Is Caused by Decreased RNA Editing Protein mRNABiochemical and Biophysical Research Communications, 1995
- Molecular Cloning of an Apolipoprotein B Messenger RNA Editing ProteinScience, 1993
- Effects of growth hormone on apolipoprotein-B (apoB) messenger ribonucleic acid editing, and apoB 48 and apoB 100 synthesis and secretion in the rat liverEndocrinology, 1992
- Quantitative studies on fatty acid metabolism in isolated parenchymal cells from normal and cirrhotic livers in ratsJournal of Hepatology, 1992
- Ontogenetic regulation of apolipoprotein B mRNA editing during human and rat development in vivo.Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 1992
- Expression of hepatic mRNAs for insulin-like growth factors-I and -II during the development of hypothyroid ratsJournal of Endocrinology, 1991
- An in vitro system for the editing of apolipoprotein B mRNACell, 1989
- A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestineCell, 1987
- Steroids and the maturation of rat tissuesJournal of Steroid Biochemistry, 1975