Application of refocused steady‐state free‐precession methods at 1.5 and 3 T to in vivo high‐resolution MRI of trabecular bone: Simulations and experiments
Open Access
- 19 May 2005
- journal article
- conference paper
- Published by Wiley in Journal of Magnetic Resonance Imaging
- Vol. 21 (6), 818-825
- https://doi.org/10.1002/jmri.20348
Abstract
Purpose To evaluate the potential of fully‐balanced steady‐state free‐precession (SSFP) sequences in in vivo high‐resolution (HR) MRI of trabecular bone at field strengths of 1.5 and 3 T by simulation and experimental methods. Materials and Methods Using simulation studies, refocused SSFP acquisition was optimized for our imaging purposes with a focus on signal‐to‐noise ratio (SNR) and SNR efficiency. The signal behavior in trabecular bone was estimated using a magnetostatic model of the trabecular bone and marrow. Eight normal volunteers were imaged at the proximal femur, calcaneus, and the distal tibia on a GE Signa scanner at 1.5 and at 3 T with an optimized single‐acquisition SSFP sequence (three‐dimensional FIESTA) and an optimized multiple‐acquisition SSFP sequence (three‐dimensional FIESTA‐c). Images were also acquired with a fast gradient echo (FGRE) sequence for evaluation of the SNR performance of SSFP methods. Results Refocused SSFP images outperformed FGRE acquisitions in both SNR and SNR efficiency at both field strengths. At 3 T, susceptibility effects were visible in FIESTA and FGRE images and much reduced in FIESTA‐c images. The magnitude of SNR boost at 3 T was closely predicted by simulations. Conclusion Single‐acquisition SSFP (at 1.5 T) and multiple‐acquisition SSFP (at 3 T) hold great potential for HR‐MRI of trabecular bone. J. Magn. Reson. Imaging 2005;21:818–825.Keywords
This publication has 22 references indexed in Scilit:
- Trabecular Bone Structure of the Distal Radius, the Calcaneus, and the SpineInvestigative Radiology, 2004
- Analysis of multiple‐acquisition SSFPMagnetic Resonance in Medicine, 2004
- Comparison of new sequences for high-resolution cartilage imagingMagnetic Resonance in Medicine, 2003
- Is TrueFISP a gradient‐echo or a spin‐echo sequence?Magnetic Resonance in Medicine, 2003
- Processing and Analysis of In Vivo High-Resolution MR Images of Trabecular Bone for Longitudinal Studies: Reproducibility of Structural Measures and Micro-Finite Element Analysis Derived Mechanical PropertiesOsteoporosis International, 2002
- Fluctuating equilibrium MRIMagnetic Resonance in Medicine, 1999
- Trabecular Bone Architecture in the Distal Radius Using Magnetic Resonance Imaging in Subjects with Fractures of the Proximal FemurOsteoporosis International, 1999
- In Vivo High Resolution MRI of the Calcaneus: Differences in Trabecular Structure in Osteoporosis PatientsJournal of Bone and Mineral Research, 1998
- Fast 3D large‐angle spin‐echo imaging (3D FLASE)Magnetic Resonance in Medicine, 1996
- An analysis of fast imaging sequences with steady‐state transverse magnetization refocusingMagnetic Resonance in Medicine, 1988