Diabetes and renal tubular cell apoptosis
- 1 January 2013
- journal article
- Published by Baishideng Publishing Group Inc. in World Journal of Diabetes
- Vol. 4 (2), 27-30
- https://doi.org/10.4239/wjd.v4.i2.27
Abstract
Apoptosis contributes to the development of diabetic nephropathy, but the mechanism by which high glucose induces apoptosis is not fully understood. Apoptosis of tubular epithelial cells is a major feature of diabetic kidney disease, and hyperglycemia triggers the generation of free radicals and oxidant stress in tubular cells. Hyperglycemia and high glucose in vitro also lead to apoptosis, a form of programmed cell death. High glucose similar to those seen with hyperglycemia in people with diabetes mellitus, lead to accelerated apoptosis, a form of programmed cell death characterized by cell shrinkage, chromatin condensation and DNA fragmentation, in variety of cell types, including renal proximal tubular epithelial cellsKeywords
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