IG/MYC Rearrangements are the Main Cytogenetic Alteration in Plasmablastic Lymphomas
- 1 November 2010
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in The American Journal of Surgical Pathology
- Vol. 34 (11), 1686-1694
- https://doi.org/10.1097/pas.0b013e3181f3e29f
Abstract
Plasmablastic lymphoma (PBL) is an aggressive lymphoma characterized by a terminally differentiated B-cell phenotype that usually occurs in the immunocompromised or elderly patients. Although the clinical and pathologic characteristics of these tumors have been defined, the genetic alterations involved in their pathogenesis are not well known. In this study, we have investigated the chromosomal alterations of MYC, BCL2, BCL6, MALT1, PAX5, and IGH loci using fluorescence in situ hybridization in 42 PBL and 3 extracavitary primary effusion lymphomas. MYC rearrangements were identified in 20 of 41 (49%) PBL and the immunoglobulin (IG) genes were the partners in most tumors. MYC rearrangements were more common in Epstein-Barr virus (EBV)-positive (14 of 19, 74%) than EBV-negative (9 of 21, 43%) tumors (P < 0.05). No rearrangements of BCL2, BCL6, MALT1, or PAX5 were detected in any PBL but gains of these loci were observed in 31% to 41% of the cases examined. Twelve of the 40 PBL in which 3 or more loci could be investigated had multiple simultaneous gains in 3 or more loci. No differences in the survival of the patients according to MYC were observed but the 4 patients with the longest survival (> 50mo) had no or low number of gains (< 3). No rearrangements of any of these loci were seen in the primary effusion lymphomas. In conclusion, PBL are genetically characterized by frequent IG/MYC translocations and gains in multiple chromosomal loci. The oncogenic activation of MYC in these lymphomas may be an important pathogenetic element associated with EBV infection.Keywords
This publication has 44 references indexed in Scilit:
- Aggressive large B-cell lymphoma with plasma cell differentiation: immunohistochemical characterization of plasmablastic lymphoma and diffuse large B-cell lymphoma with partial plasmablastic phenotypeHaematologica, 2010
- B-cell Lymphomas With Concurrent IGH-BCL2 and MYC Rearrangements Are Aggressive Neoplasms With Clinical and Pathologic Features Distinct From Burkitt Lymphoma and Diffuse Large B-cell LymphomaThe American Journal of Surgical Pathology, 2010
- Genome wide DNA‐profiling of HIV‐related B‐cell lymphomasBritish Journal of Haematology, 2009
- Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survivalBlood, 2009
- Clinicopathological features of lymphoma/leukemia patients carrying both BCL2 and MYC translocationsHaematologica, 2009
- Plasmablastic Lymphoma Affecting the Lung and Bone Marrow With CD10 Expression and t(8;14)(q24;q32) TranslocationInternational Journal of Surgical Pathology, 2008
- Translocation detection in lymphoma diagnosis by split-signal FISH: a standardised approachJournal of Hematopathology, 2008
- Secondary genomic rearrangements involving immunoglobulin or MYC loci show similar prevalences in hyperdiploid and nonhyperdiploid myeloma tumorsGenes, Chromosomes and Cancer, 2008
- Three restricted forms of Epstein–Barr virus latency counteracting apoptosis in c-myc-expressing Burkitt lymphoma cellsProceedings of the National Academy of Sciences of the United States of America, 2006
- FISH Analysis for the Detection of Lymphoma-Associated Chromosomal Abnormalities in Routine Paraffin-Embedded TissueThe Journal of Molecular Diagnostics, 2006