Treatment of refractory melasma with the MedLite C6 Q-switched Nd:YAG laser and alpha arbutin: A prospective study
- 1 January 2010
- journal article
- clinical trial
- Published by Informa UK Limited in Journal of Cosmetic and Laser Therapy
- Vol. 12 (3), 126-131
- https://doi.org/10.3109/14764172.2010.487910
Abstract
Objective: To evaluate the effectiveness of a Q-switched Nd:YAG laser (MedLite C6; HOYA ConBio, Fremont, CA, USA) and 7% alpha arbutin solution (Skin Advance Laboratory, Japan) in the treatment of melasma. Methods: This was a prospective study of 35 refractory melasma cases treated with 10 weekly laser sessions, two monthly follow-up treatments and topical 7% alpha arbutin solution. Clinical photographs and severity grading on a 5-point scale were carried out by an independent observer at each visit. Results: At 6 months, 30% of study subjects received results in the excellent clearance category (> 81% reduction of melasma) and 36.7% received good (51–80% reduction) clearance. Mild and transient side effects included discomfort during treatment, erythema, whitening of fine hair and urticaria. Three cases of mottling hypo-pigmentation (8.57%) and two cases of recurrence of melasma (5.71%) were recorded. Conclusion: Combination therapy with the MedLite C6 and 7% alpha arbutin solution is an effective and well-tolerated treatment for refractory melasma.Keywords
This publication has 17 references indexed in Scilit:
- Therapeutical Approaches in MelasmaDermatologic Clinics, 2007
- A comparison of triple combination cream and hydroquinone 4% cream for the treatment of moderate to severe facial melasmaJournal of Cosmetic Dermatology, 2007
- The treatment of melasma: A review of clinical trialsJournal of the American Academy of Dermatology, 2006
- A clinical, prospective, randomized, double‐blind trial comparing skin whitening complex with hydroquinone vs. placebo in the treatment of melasmaInternational Journal of Dermatology, 2003
- Syntheses of Arbutin-.ALPHA.-glycosides and a Comparison of Their Inhibitory Effects with Those of .ALPHA.-Arbutin and Arbutin on Human TyrosinaseCHEMICAL & PHARMACEUTICAL BULLETIN, 2003
- Melasma: histopathological characteristics in 56 Korean patientsBritish Journal of Dermatology, 2002
- Treatment of Melasma Using Kojic Acid in a Gel Containing Hydroquinone and Glycolic AcidDermatologic Surgery, 1999
- Effect of Arbutin on Melanogenic Proteins in Human MelanocytesPigment Cell Research, 1998
- MelasmaArchives of Dermatology, 1995
- Mechanism of inhibition of melanogenesis by hydroquinoneBiochimica et Biophysica Acta (BBA) - General Subjects, 1991