The identification and biochemical characterization of drug-like compounds that inhibit botulinum neurotoxin serotype A endopeptidase activity
- 1 April 2010
- journal article
- Published by Elsevier BV in Toxicon
- Vol. 55 (4), 818-826
- https://doi.org/10.1016/j.toxicon.2009.11.017
Abstract
No abstract availableKeywords
This publication has 33 references indexed in Scilit:
- Pharmacophore-guided lead optimization: The rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloproteaseBioorganic & Medicinal Chemistry Letters, 2009
- Three‐Dimensional Database Mining Identifies a Unique Chemotype that Unites Structurally Diverse Botulinum Neurotoxin Serotype A Inhibitors in a Three‐Zone PharmacophoreChemMedChem, 2008
- A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 SubstrateStructure, 2008
- A Refined Pharmacophore Identifies Potent 4-Amino-7-chloroquinoline-Based Inhibitors of the Botulinum Neurotoxin Serotype A MetalloproteaseJournal of Medicinal Chemistry, 2007
- Inhibition of Metalloprotease Botulinum Serotype A from a Pseudo-peptide Binding Mode to a Small Molecule That Is Active in Primary NeuronsOnline Journal of Public Health Informatics, 2007
- Enhancement of the Endopeptidase Activity of Purified Botulinum Neurotoxins A and E by an Isolated Component of the Native Neurotoxin Associated ProteinsBiochemistry, 2004
- Enhancement of the Endopeptidase Activity of Botulinum Neurotoxin by Its Associated Proteins and DithiothreitolBiochemistry, 1999
- A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening AssaysSLAS Discovery, 1999
- Structure-Function Relationship of Clostridial NeurotoxinsJournal of Toxicology: Toxin Reviews, 1999
- Tetanus and botulism neurotoxins: a new group of zinc proteasesTrends in Biochemical Sciences, 1993