Exploratory study of the relationship of fat-free mass to speed of brain processing in preterm infants
Open Access
- 13 August 2013
- journal article
- Published by Springer Science and Business Media LLC in Pediatric Research
- Vol. 74 (5), 576-583
- https://doi.org/10.1038/pr.2013.138
Abstract
Preterm infants are at risk for long-term neurodevelopmental impairment as a function of postnatal nutritional status. Despite adequate neonatal weight gain, preterm infants have altered body composition, with lower fat-free mass (FFM) and higher adiposity at term corrected gestational age (CGA) than their term counterparts. The relationship between postnatal body composition and speed of brain processing in preterm infants is unknown. Anthropometric measurements and body composition testing via air displacement plethysmography were performed on 16 appropriate-for-gestational age (GA) preterm (mean GA: 30.4 ± 2.8 wk) infants at term and 4 mo CGA. Infant visual pathway development was assessed at 4 mo CGA using pattern-reversal visual evoked potential (VEP); P100 (positive peak) latency was used to index neuronal speed of processing. Increased FFM at discharge (P = 0.02) and 4 mo CGA (P = 0.006) was associated with shorter latencies to the P100 peak. P100 latency was not related to total body weight, fat mass, or body fat percentage. FFM reflects protein accretion and indexes growth of organs, including the brain. The association of shorter VEP latency (i.e., faster neuronal processing) with higher FFM (i.e., better protein status) may be attributed to the positive effects of protein status on neuronal growth and differentiation.Keywords
This publication has 33 references indexed in Scilit:
- Preterm Birth and Body Composition at Term Equivalent Age: A Systematic Review and Meta-analysisPediatrics, 2012
- The Relationship of Poor Linear Growth Velocity with Neonatal Illness and Two-Year Neurodevelopment in Preterm InfantsNeonatology, 2012
- Infant Growth Before and After Term: Effects on Neurodevelopment in Preterm InfantsPediatrics, 2011
- Body Composition Changes in Preterm Infants Following Hospital DischargeJournal of Pediatric Gastroenterology and Nutrition, 2011
- Intrauterine, Early Neonatal, and Postdischarge Growth and Neurodevelopmental Outcome at 5.4 Years in Extremely Preterm Infants After Intensive Neonatal Nutritional SupportPediatrics, 2009
- Growth in the Neonatal Intensive Care Unit Influences Neurodevelopmental and Growth Outcomes of Extremely Low Birth Weight InfantsPediatrics, 2006
- Postnatal growth in VLBW infants: significant association with neurodevelopmental outcomeThe Journal of Pediatrics, 2003
- Randomised controlled trial of an aggressive nutritional regimen in sick very low birthweight infantsArchives of Disease in Childhood: Fetal & Neonatal, 1997
- Effect of Very Low Birth Weight and Subnormal Head Size on Cognitive Abilities at School AgeNew England Journal of Medicine, 1991
- Relation of Lean Body Mass to Height in Children and AdolescentsPediatric Research, 1972