Intake of Fruits and Vegetables and Risk of Breast Cancer
- 14 February 2001
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 285 (6), 769-776
- https://doi.org/10.1001/jama.285.6.769
Abstract
Context Some epidemiologic studies suggest that elevated fruit and vegetable consumption is associated with a reduced risk of breast cancer. However, most have been case-control studies in which recall and selection bias may influence the results. Additionally, publication bias may have influenced the literature on associations for specific fruit and vegetable subgroups. Objective To examine the association between breast cancer and total and specific fruit and vegetable group intakes using standardized exposure definitions. Data Sources/Study Selection Eight prospective studies that had at least 200 incident breast cancer cases, assessed usual dietary intake, and completed a validation study of the diet assessment method or a closely related instrument were included in these analyses. Data Extraction Using the primary data from each of the studies, we calculated study-specific relative risks (RRs) that were combined using a random-effects model. Data Synthesis The studies included 7377 incident invasive breast cancer cases occurring among 351 825 women whose diet was analyzed at baseline. For comparisons of the highest vs lowest quartiles of intake, weak, nonsignificant associations were observed for total fruits (pooled multivariate RR, 0.93; 95% confidence interval [CI], 0.86-1.00; P for trend = .08), total vegetables (RR, 0.96; 95% CI, 0.89-1.04; P for trend = .54), and total fruits and vegetables (RR, 0.93; 95% CI, 0.86-1.00; P for trend = .12). No additional benefit was apparent in comparisons of the highest and lowest deciles of intake. No associations were observed for green leafy vegetables, 8 botanical groups, and 17 specific fruits and vegetables. Conclusion These results suggest that fruit and vegetable consumption during adulthood is not significantly associated with reduced breast cancer risk.This publication has 22 references indexed in Scilit:
- Dietary Carotenoids and Vitamins A, C, and E and Risk of Breast CancerJNCI Journal of the National Cancer Institute, 1999
- A prospective study of association of monounsaturated fat and other types of fat with risk of breast cancer.Archives of Internal Medicine, 1998
- Vitamins C and E, retinol, beta-carotene and dietary fibre in relation to breast cancer risk: a prospective cohort studyBritish Journal of Cancer, 1997
- Cohort Studies of Fat Intake and the Risk of Breast Cancer — A Pooled AnalysisThe New England Journal of Medicine, 1996
- The University of Minnesota Cancer Prevention Research Unit vegetable and fruit classification scheme (United States)Cancer Causes & Control, 1995
- Dietary fiber, vitamins A, C, and E, and risk of breast cancer: a cohort studyCancer Causes & Control, 1993
- Diet in the Epidemiology of Postmenopausal Breast Cancer in the New York State CohortAmerican Journal of Epidemiology, 1992
- Intake of vegetables, fruits, beta-carotene, vitamin C and vitamin supplements and cancer incidence among the elderly: a prospective studyBritish Journal of Cancer, 1992
- Dietary habits and breast cancer incidence among seventh-day adventistsCancer, 1989
- Modern epidemiology?Journal of Epidemiology and Community Health, 1988