A polymorphism in ACE2 is associated with a lower risk for fatal cardiovascular events in females: the MORGAM project
Open Access
- 13 April 2011
- journal article
- research article
- Published by SAGE Publications in Journal of the Renin-Angiotensin-Aldosterone System
- Vol. 12 (4), 504-509
- https://doi.org/10.1177/1470320311405557
Abstract
Angiotensin II, a vasoconstrictor and the main effector molecule of the renin–angiotensin system, is known to influence inflammation, thrombosis, low-density lipoprotein oxidation and growth factors, all of which contribute to cardiovascular disease. The associations of polymorphisms in the angiotensin-converting enzyme 2 (ACE2) gene with cardiovascular risk have not been fully determined. Single nucleotide polymorphisms (SNPs) in ACE2 were genotyped in participants of the prospective MORGAM study (n = 5092) from five cohorts: ATBC, FINRISK, Northern Sweden, PRIME/Belfast and PRIME/France. Using a case-cohort design, associations were sought between SNPs and haplotypes with cardiovascular events during follow-up (Cox proportional hazards model). The comparison group were a subset of all MORGAM participants who were selected to ensure similar age and sex distributions among the cases and controls. The A allele of the rs2285666 SNP (HR = 0.3, p = 0.04) was significantly associated with the risk of cardiovascular death in female subjects. These findings complement those found in other studies of SNPs in the ACE2 gene in relation to cardiovascular disease risk. As females carry two copies of the ACE2 gene, and given its plausible biological role in cardiovascular disease risk, further studies of ACE2 should be prioritised.Keywords
This publication has 32 references indexed in Scilit:
- Telmisartan, ramipril, or both in patients at high risk for vascular eventsCurrent Hypertension Reports, 2008
- Ramipril administration to atherosclerotic mice reduces oxidized low-density lipoprotein uptake by their macrophages and blocks the progression of atherosclerosisAtherosclerosis, 2002
- The multiple actions of angiotensin II in atherosclerosisRegulatory Peptides, 2000
- Effects of an Angiotensin-Converting–Enzyme Inhibitor, Ramipril, on Cardiovascular Events in High-Risk PatientsThe New England Journal of Medicine, 2000
- Angiotensin Induces Inflammatory Activation of Human Vascular Smooth Muscle CellsArteriosclerosis, Thrombosis, and Vascular Biology, 1999
- Attenuation of myocardial stunning by the AT1 receptor antagonist candesartan.Basic Research in Cardiology, 1999
- Amelioration by Quinapril of Myocardial Infarction Induced by Coronary Occlusion/Reperfusion in a Rabbit Model of AtherosclerosisCirculation, 1999
- The Renin-Angiotensin SystemThe New England Journal of Medicine, 1974
- The Renin-Angiotensin SystemThe New England Journal of Medicine, 1974
- The substance causing renal hypertensionJournal Of Physiology-London, 1940