Retrobulbar, Intracranial, and Cutaneous Secondary Plasmacytomas in a Patient with Atypical Multiple Myeloma

Abstract

Extramedullary plasmacytomas occur either as solitary (primary) tumors or as secondary manifestations of multiple myeloma. Involvement of the orbit is very rare in both entities.¹ Patients characteristically present with exophthalmos, increased tearing, blurred vision, or diplopia.² Although neurologic symptoms in multiple myeloma can be due to hyperviscosity or hypercalcemia, only 50 cases of multiple myeloma involving the central nervous system have been documented, and most of them were of meningeal origin.³ We describe a patient with multiple myeloma and secondary orbital, intracranial, and cutaneous plasmacytomas.