Primary malignant germinal tumors of the mediastinum.A study of 24 cases
- 1 September 1975
- Vol. 36 (3), 1162-1168
- https://doi.org/10.1002/1097-0142(197509)36:3<1162::aid-cncr2820360351>3.0.co;2-0
Abstract
The malignant germinal tumors found in the testis (seminoma, teratocarcinoma, embryonal carcinoma, choriocarcinoma, and mixtures of these) can originate in the anterior mediastinum. An occult testicular tumor must be sought, but primary mediastinal germinal tumors constitute a true entity. The details of 24 such patients treated at Walter Reed General Hospital are presented. Of 19 patients who died, 2 were women; postmortem examination of the testes of 13 men failed to reveal a primary tumor. Five patients are alive and well with no testicular abnormality. It is important to distinguish the histopathologic types. Seminomas are readily controlled with modest doses of irradiation. Embryonal carcinomas are also radiocurable with somewhat higher doses; 2 long-term disease-free survivors are reported. Teratocar-cinomas are highly malignant and require higher doses for control. Choriocar-cinomas progress so rapidly that chemotherapy is necessary.Keywords
This publication has 16 references indexed in Scilit:
- Primary mediastinal seminomaThe Journal of Thoracic and Cardiovascular Surgery, 1973
- Primary Malignant Tumors of the MediastinumThe Annals of Thoracic Surgery, 1972
- Occult seminoma of the testis masquerading as primary extragonadal germinal neoplasmsCancer, 1972
- The Asymptomatic Mediastinal MassArchives of Surgery, 1971
- Treatment Germ Cell of Testicular MalignanciesPublished by American Medical Association (AMA) ,1970
- DEFINITIVE RADIOTHERAPY OF PRIMARY MEDIASTINAL SEMINOMAAmerican Journal of Roentgenology, 1969
- Mediastinal Tumors—Problems in Diagnosis and Treatment* *From the Departments of Surgery and Medicine, UCLA Center for the Health Sciences.Diseases of the Chest, 1966
- Germinoma of the Mediastinum1American Review of Respiratory Disease, 1963
- Primary extragenital choriocarcinoma in the male subject: Case report and review of the literatureAmerican Journal Of Medicine, 1962
- The comparative morphogenesis of extragenital and gonadal teratoid tumorsCancer, 1951