Chronic repetitive reaching and grasping results in decreased motor performance and widespread tissue responses in a rat model of MSD
Open Access
- 1 January 2003
- journal article
- Published by Wiley in Journal of Orthopaedic Research
- Vol. 21 (1), 167-176
- https://doi.org/10.1016/s0736-0266(02)00086-4
Abstract
This study investigated changes in motor skills and tissues of the upper extremity (UE) with regard to injury and inflammatory reactions resulting from performance of a voluntary forelimb repetitive reaching and grasping task in rats. Rats reached for food at a rate of 4 reaches/min, 2 h/day, and 3 days/week for up to 8 weeks during which reach rate, task duration and movement strategies were observed. UE tissues were collected bilaterally at weekly time points of 3–8 weeks and examined for morphological changes. Serum was tested for levels of interleukin‐1α (IL‐1) protein. The macrophage‐specific antibody, ED1, was used to identify infiltrating macrophages and the ED2 antibody was used to identify resident macrophages. Rats were unable to maintain baseline reach rate in weeks 5 and 6 of task performance. Alternative patterns of movement emerged. Fraying of tendon fibrils was observed after 6 weeks in the mid‐forelimb. After 4 weeks, a general elevation of ED1‐IR macrophages were seen in all tissues examined bilaterally including the contralateral, uninvolved forelimb and hindlimbs. Significantly more resident macrophages were seen at 6 and 8 weeks in the reach limb. At 8 weeks, serum levels of IL‐1α increased significantly above week 0. Our results demonstrate that performance of repetitive tasks elicits motor decrements, signs of injury and a cellular and tissue responses associated with inflammation. © 2002 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.Keywords
This publication has 37 references indexed in Scilit:
- Cell adhesion molecules in neural plasticity and pathology: similar mechanisms, distinct organizations?Progress in Neurobiology, 1998
- The scientific basis for making guidelines and standards to prevent work-related musculoskeletal disordersErgonomics, 1997
- Fibrosis and intercellular collagen connections from four weeks of muscle strainsMuscle & Nerve, 1996
- Immunohistochemical Study of Rat Renal Interstitial Fibrosis Induced by Repeated Injection of Cisplatin, with Special Reference to the Kinetics of Macrophages and MyofibroblastsToxicologic Pathology, 1996
- Delayed Muscle SorenessSports Medicine, 1995
- The grasping test: a simple behavioral method for objective quantitative assessment of peripheral nerve regeneration in the ratJournal of Neuroscience Methods, 1995
- Skilled reaching in rats and humans: evidence for parallel development or homologyBehavioural Brain Research, 1992
- The structure of skilled forelimb reaching in the rat: A proximally driven movement with a single distal rotatory componentBehavioural Brain Research, 1990
- Secretory products of macrophages.JCI Insight, 1987
- Hand wrist cumulative trauma disorders in industry.Occupational and Environmental Medicine, 1986