Dicentric Chromosome 3 Associated with Binucleated Lymphocytes in Atypical B-cell Chronic Lymphoproliferative Disorder
- 1 January 2002
- journal article
- case report
- Published by Taylor & Francis Ltd in Leukemia & Lymphoma
- Vol. 43 (9), 1749-1754
- https://doi.org/10.1080/1042819021000006501
Abstract
Binucleated lymphocytes on blood smear are known in PPBL characterized by stable and polyclonal lymphocytosis, polyclonal increase of serum IgM, HLA DR7 and strong correlation with additional i(3q) and premature chromosome condensation. In this disorder some reports of clonal Ig rearrangement suggest a follow up of these patients with immunological and genetic studies. Binucleated lymphocytes are rarely described in other clonal B-CLPD as B-CLL or marginal zone B-cell lymphoma (MZL). Chromosome 3 abnormality is never described in B-CLL but trisomy 3 represents the most consistent abnormality characterizing the MZL. We report in a man without previous medical history an unusual B-CLPD with monoclonal lymphocytosis CD5 m, characteristic cytology (particularly binucleated lymphocytes) and chromosomic abnormality as dicentric chromosome 3 never previously described in B-CLPD. In this case lymphocytosis is persistent and stable over 24 months, cytologic immunologic and chromosomic abnormalities are unchanged. We discuss the nosologic place of this atypical B-CLPD closely related to PPBL and MZL with at the moment, after 24 months, a quiet evolution that imply nevertheless a careful follow up with regular cytologic, immunological and genetic studies to clarify the issue.Keywords
This publication has 28 references indexed in Scilit:
- Persistent polyclonal B lymphocytosis with binucleated lymphocytes: a study of 25 casesBritish Journal of Haematology, 1999
- Detection ofBCL-6 rearrangements andp53 mutations in malt-lymphomasAmerican Journal of Hematology, 1997
- Distribution of the cytogenetic abnormality +i(3)(q10) in persistent polyclonal B‐cell lymphocytosis: a FICTION study in three casesBritish Journal of Haematology, 1997
- Multiple bcl‐2/Ig gene rearrangements in persistent polyclonal B‐cell lymphocytosisBritish Journal of Haematology, 1997
- Trisomy 3 in marginal zone B-cell lymphoma: a study based on cytogenetic analysis and fluorescence in situ hybridizationBritish Journal of Haematology, 1996
- Chronic B-Cell lymphocytosis with binucleated lymphocytes (lwbl): a review of 38 casesLeukemia & Lymphoma, 1996
- Isochromosome i(3q) and premature chromosome condensation are recurrent findings in chronic b-cell lymphocytosis with binucleated lymphocytesLeukemia & Lymphoma, 1996
- Fluorescence in situ hybridization analysis of whole‐arm 7;12 translocations in hematologic malignanciesGenes, Chromosomes and Cancer, 1995
- dic(9; 20): A new recurrent chromosome abnormality in adult acute lymphoblastic leukemiaGenes, Chromosomes and Cancer, 1995
- Persistent Polyclonal Lymphocytosis of B LymphocytesNew England Journal of Medicine, 1982