Bone Metabolism After Bariatric Surgery
Open Access
- 28 March 2014
- journal article
- review article
- Published by Oxford University Press (OUP) in Journal of Bone and Mineral Research
- Vol. 29 (7), 1507-1518
- https://doi.org/10.1002/jbmr.2226
Abstract
Bariatric surgery is a popular and effective treatment for severe obesity but may have negative effects on the skeleton. This review summarizes changes in bone density and bone metabolism from animal and clinical studies of bariatric surgery, with specific attention to Roux‐en‐Y gastric bypass (RYGB), adjustable gastric banding (AGB), and sleeve gastrectomy (SG). Skeletal imaging artifacts from obesity and weight loss are also considered. Despite challenges in bone density imaging, the preponderance of evidence suggests that bariatric surgery procedures have negative skeletal effects that persist beyond the first year of surgery, and that these effects vary by surgical type. The long‐term clinical implications and current clinical recommendations are presented. Further study is required to determine mechanisms of bone loss after bariatric surgery. Although early studies focused on calcium/vitamin D metabolism and mechanical unloading of the skeleton, it seems likely that surgically induced changes in the hormonal and metabolic profile may be responsible for the skeletal phenotypes observed after bariatric surgery. © 2014 American Society for Bone and Mineral Research.Keywords
This publication has 134 references indexed in Scilit:
- Melanocortin-4 Receptor Signaling Is Required for Weight Loss after Gastric Bypass SurgeryJournal of Clinical Endocrinology & Metabolism, 2012
- Bone Mineral Changes in Spine and Proximal Femur in Individual Obese Women after Laparoscopic Sleeve Gastrectomy: A Short-Term StudyObesity Surgery, 2012
- Increased PTH and 1.25(OH)2D Levels Associated With Increased Markers of Bone Turnover Following Bariatric SurgeryObesity, 2011
- Assessment of Different Bariatric Surgeries in the Treatment of Obesity and Insulin Resistance in MiceAnnals of Surgery, 2011
- BMI and fracture risk in older men: The osteoporotic fractures in men study (MrOS)Journal of Bone and Mineral Research, 2010
- Comparison of DXA and water measurements of body fat following gastric bypass surgery and a physiological model of body water, fat, and muscle compositionJournal of Applied Physiology, 2010
- Development of a Sleeve Gastrectomy Weight Loss Model in Obese Zucker RatsJournal of Surgical Research, 2009
- Perioperative Safety in the Longitudinal Assessment of Bariatric SurgeryNew England Journal of Medicine, 2009
- Body Composition Measured by Dual‐energy X‐ray Absorptiometry Half‐body Scans in Obese AdultsObesity, 2009
- Body Composition, Dietary Intake, and Energy Expenditure After Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Vertical Banded GastroplastyAnnals of Surgery, 2006