The impact of IL-1 modulation on the development of lipopolysaccharide-induced cognitive dysfunction
Open Access
- 1 January 2010
- journal article
- Published by Springer Science and Business Media LLC in Critical Care
- Vol. 14 (3), R88
- https://doi.org/10.1186/cc9019
Abstract
The impact of pro-inflammatory cytokines on neuroinflammation and cognitive function after lipopolysaccharide (LPS) challenge remains elusive. Herein we provide evidence that there is a temporal correlation between high-mobility group box 1 (HMGB-1), microglial activation, and cognitive dysfunction. Disabling the interleukin (IL)-1 signaling pathway is sufficient to reduce inflammation and ameliorate the disability.Keywords
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