Human Embryonic Stem Cell-Derived Neurons as a Tool for Studying Neuroprotection and Neurodegeneration
- 30 April 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in Molecular Neurobiology
- Vol. 42 (1), 97-102
- https://doi.org/10.1007/s12035-010-8136-2
Abstract
The capacity to generate myriad differentiated cell types, including neurons, from human embryonic stem (hES) cell lines offers great potential for developing cell-based therapies and also for increasing our understanding of human developmental mechanisms. In addition, the emerging development of this technology as an experimental tool represents a potential opportunity for neuroscientists interested in mechanisms of neuroprotection and neurodegeneration. Potentially unlimited generation of well-defined functional neurons from hES and patient-specific induced pluripotent cells offers new systems to study disease mechanisms, signalling pathways and receptor pharmacology within a human cellular environment. Such systems may help in overcoming interspecies differences. Far from replacing rodent in vivo and primary culture systems, hES and induced disease-specific pluripotent stem cell-derived neurons offer a complementary resource to overcome issues of interspecies differences, accelerate drug discovery, study of disease mechanism and provide basic insight into human neuronal physiology.Keywords
This publication has 47 references indexed in Scilit:
- Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCsNature, 2009
- Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signalingNature Biotechnology, 2009
- Induced pluripotent stem cells from a spinal muscular atrophy patientNature, 2008
- Tau isoform regulation is region‐ and cell‐specific in mouse brainJournal of Comparative Neurology, 2008
- Neural differentiation of human embryonic stem cellsJournal of Cellular Biochemistry, 2008
- Synaptic NMDA receptor activity boosts intrinsic antioxidant defensesNature Neuroscience, 2008
- Tissue-specific transcriptional regulation has diverged significantly between human and mouseNature Genetics, 2007
- An In Vitro Model of Human Dopaminergic Neurons Derived from Embryonic Stem Cells: MPP+ Toxicity and GDNF NeuroprotectionNeuropsychopharmacology, 2006
- The evolution of spliceosomal introns: patterns, puzzles and progressNature Reviews Genetics, 2006
- Characterization and culture of human embryonic stem cellsNature Biotechnology, 2005