Cytotoxic Clerodane Diterpenoids from Casearia membranacea
- 15 October 2005
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 68 (11), 1665-1668
- https://doi.org/10.1021/np058063o
Abstract
Bioassay-guided fractionation of the EtOAc extract of Casearia membranacea leaves and twigs afforded three new clerodane diterpenes, caseamembrins M-O (1-3), and the known rel-(2S,5R,6R,8S,9S,10R,18S,19R)-2-(2-methylbutyryloxy)-6-hydroxy-18,19-di-O-acetyl-18,19-epoxycleroda-3,13(16),14-triene (4) and caseamembrin D (5). The structures of 1-3, including the relative configurations, were established by extensive NMR spectroscopic analyses. The cytotoxic activities of the isolated diterpenoids against human oral epidermoid (KB), medulla (Med), and colon (DLD-1) cancer cell lines were evaluated.Keywords
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