Neuronal correlates of asocial behavior in a BTBR T+Itpr3tf/J mouse model of autism
Open Access
- 6 August 2015
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Behavioral Neuroscience
Abstract
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized, in part, by an inability to adequately respond to social cues. Patients diagnosed with ASD are often devoid of empathy and impaired in understanding other people’s emotional perspective. The neuronal correlates of this impairment are not fully understood. Replicating such behavioral phenotype in a mouse model of autism would allow us an insight into the neuronal background of the problem. Here we tested BTBR T+Itpr3tf/J (BTBR) and c57BL/6J (B6) mice in two behavioral paradigms: The Transfer of Emotional Information test and the Social Proximity test. In both tests BTBR mice displayed asocial behavior. We analyzed c-Fos protein expression in several brain regions after each of these tests, to find that, unlike B6 mice, BTBR mice react to a stressed cagemate exposure in the Transfer of Emotional Information test with no increase of c-Fos expression in either the prefrontal cortex or the amygdala. After Social Proximity exposure however, we observed a strong increase in c-Fos expression in the CA3 field of hippocampus and two hypothalamic regions of BTBR brains. This response was accompanied by a strong activation of periaqueductal regions related to defensiveness, which suggests that BTBR mice find unavoidable social interaction highly aversive.Keywords
This publication has 50 references indexed in Scilit:
- Ethotransmission: communication of emotional states through ultrasonic vocalization in ratsCurrent Opinion in Neurobiology, 2013
- Diagnostic and Statistical Manual of Mental DisordersPublished by American Psychiatric Association Publishing ,2013
- What ethologically based models have taught us about the neural systems underlying fear and anxietyBrazilian Journal of Medical and Biological Research, 2012
- BTBR T+tf/J mice: Autism-relevant behaviors and reduced fractone-associated heparan sulfateNeuroscience & Biobehavioral Reviews, 2012
- Etiological heterogeneity in autism spectrum disorders: More than 100 genetic and genomic disorders and still countingBrain Research, 2011
- Exaggerated responses to stress in the BTBR T+tf/J mouse: An unusual behavioral phenotypeBehavioural Brain Research, 2009
- Social modulation of associative fear learning by pheromone communicationLearning & Memory, 2008
- Scent marking behavior as an odorant communication in miceNeuroscience & Biobehavioral Reviews, 2008
- Long-term effects of social stress on brain and behavior: a focus on hippocampal functioningNeuroscience & Biobehavioral Reviews, 2005
- The Dorsomedial Hypothalamic Nucleus Revisited: 1998 UpdateExperimental Biology and Medicine, 1998