Rapid formation and remodeling of postsynaptic densities in developing dendrites
- 27 August 2001
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Neuroscience
- Vol. 4 (10), 1006-1013
- https://doi.org/10.1038/nn717
Abstract
The dynamics of postsynaptic density (PSD) formation and remodeling were investigated in live developing hippocampal tissue slices. Time lapse imaging of transfected neurons expressing GFP-tagged PSD95, a prominent PSD protein, revealed that up to 40% of PSDs in developing dendrites are structurally dynamic; they rapidly (de novo, or by direct extension of spines or spine precursors carrying preformed PSDs from the shaft. PSDs are therefore highly dynamic structures that can undergo rapid structural alteration within dendrite shafts, spines and spine precursors, permitting rapid formation and remodeling of synaptic connections in developing CNS tissues.Keywords
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