NovaSil clay does not affect the concentrations of vitamins A and E and nutrient minerals in serum samples from Ghanaians at high risk for aflatoxicosis
- 19 June 2008
- journal article
- research article
- Published by Taylor & Francis Ltd in Food Additives & Contaminants: Part A
- Vol. 25 (7), 872-884
- https://doi.org/10.1080/02652030701854758
Abstract
To assess the potential interference of NovaSil (NS) clay with micronutrients in humans, vitamins A and E and minerals (15 nutrient and 15 non-nutrient minerals) were measured in serum samples from a 3-month intervention trial with NS. Participants (n = 177) were randomly divided into three groups that received 3.0 g NS day−1 (high dose, HD), 1.5 g NS day−1 (low dose, LD), or placebo (PL). Levels of vitamins A and E in serum were comparable among the three study groups at baseline, 1 month and 3 months of NS intervention. Gender-stratified non-parametric mixed-effect model analysis showed no significant effects of dose and dose–time interaction for levels of vitamins A and E. A significant time effect was detected; however, it was limited to an increase in vitamin E in the male participants over the course of the study. No significant differences were found in levels of the nutrient and non-nutrient minerals between the HD and PL groups at baseline and 3 months of NS intervention, except for strontium levels. Strontium was significantly increased (p < 0.001) in the HD group (male = 113.65 ± 28.00 µg l−1; female = 116.40 ± 24.26 µg l−1) compared with the PL group (male = 83.55 ± 39.90 µg l−1; female = 90.47 ± 25.68 µg l−1) following the 3-month intervention with NS. These results, combined with safety and efficacy data, confirm that NS clay is highly effective in reducing aflatoxin exposure and acts as a selective enterosorbent that does not affect the serum concentrations of important vitamins and nutrient minerals in humans.Keywords
This publication has 45 references indexed in Scilit:
- NovaSil clay intervention in Ghanaians at high risk for aflatoxicosis. I. Study design and clinical outcomesFood Additives & Contaminants: Part A, 2007
- Case–Control Study of an Acute Aflatoxicosis Outbreak, Kenya, 2004Environmental Health Perspectives, 2005
- Postweaning Exposure to Aflatoxin Results in Impaired Child Growth: A Longitudinal Study in Benin, West AfricaEnvironmental Health Perspectives, 2004
- TOXICOLOGICAL EVALUATION AND METAL BIOAVAILABILITY IN PREGNANT RATS FOLLOWING EXPOSURE TO CLAY MINERALS IN THE DIETJournal of Toxicology and Environmental Health, Part A, 2004
- DNA Fingerprinting Analysis of Vegetative Compatibility Groups in Aspergillus flavus from a Peanut Field in GeorgiaPlant Disease, 2002
- Dietary clay in the chemoprevention of aflatoxin-induced diseaseToxicological Sciences, 1999
- Strontium and BoneJournal of Bone and Mineral Research, 1999
- DNA damage by mycotoxinsMutation Research - Reviews in Mutation Research, 1999
- Comparison of Two Hydrated Sodium Calcium Aluminosilicate Compounds to Experimentally Protect Growing Barrows from AflatoxicosisJournal of Veterinary Diagnostic Investigation, 1994
- Suppression of serum iron-binding capacity and bone marrow cellularity in pigs fed aflatoxinBulletin of Environmental Contamination and Toxicology, 1988