Deoxyribonucleic Acid Antibody: A Method to Detect Its Primary Interaction with Deoxyribonucleic Acid
- 23 August 1968
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 161 (3843), 806-807
- https://doi.org/10.1126/science.161.3843.806
Abstract
Antibody to DNA in human serums can be detected by the ammonium sulfate method. This sensitive and specific technique, which measures the primary interaction between DNA and antibody to DNA, is based on the observation that free DNA is soluble in 50-percent saturated ammonium sulfate whereas antibody-bound DNA is insoluble.Keywords
This publication has 7 references indexed in Scilit:
- Antibodies to Native and Denatured Deoxyribonucleic Acid in Systemic Lupus Erythematosus*JCI Insight, 1967
- Deoxybonucleic acid (DNA) and antibodies to DNA in the serum of patients with systemic lupus erythematosus.JCI Insight, 1966
- A Comparison of Some Commonly Used Methods for Detecting Antibodies to Bovine Albumin in Human SerumThe Journal of Immunology, 1966
- Biochemical Aspects of Competence in the Bacillus subtilis Transformation SystemPublished by Elsevier BV ,1963
- Antibodies to denatured deoxyribonucleic acid in lupus erythematosus serum. IV. Evidence for purine determinants in DNAArchives of Biochemistry and Biophysics, 1963
- THE PRECIPITIN REACTION BETWEEN DNA AND A SERUM FACTOR IN SYSTEMIC LUPUS ERYTHEMATOSUSThe Journal of Experimental Medicine, 1959
- A Quantitative Immunochemical Measure of thePrimary Interaction Between I*BSA and AntibodyThe Journal of Infectious Diseases, 1958