The intersection of stress, sex and immunity in fishes
- 11 January 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Immunogenetics
- Vol. 73 (1), 111-129
- https://doi.org/10.1007/s00251-020-01194-2
Abstract
While sexual dimorphism in immune responses has been documented in other vertebrates, evidence for a similar phenomenon in fish is lacking. Here, we review the relationship between immunity, stress, spawning, and sex hormones in fish to gain a better understanding of sex-based differences in fish immune responses and its consequences for aquaculture. It is well known that there is a strong link between the stress response and immune function in fish. In addition, research to date has demonstrated that sexual dimorphism in the stress response exists in many species; yet, the relationship between the sexual dimorphic stress responses and immune function has rarely been explored together. Aside from stress, spawning is also known to trigger changes in fish immune responses. Estrogens and androgens have been shown to modulate the immune system which could account for differences between the two sexes of fish when spawning; however, evidence regarding the sexual dimorphism of these changes varies between fishes and is likely related to the spawning strategy employed by a given species. Sex hormones are also used in aquaculture practices to produce monosex populations, and exposure to these hormones early in development has been shown to impact the development of immune organs in several fishes. While female fish are generally thought to be more robust than males, aquaculture practices should also consider the role that maternal stress has on the immune function of the offspring and what role this plays in compromising the immune response of farmed fish.Keywords
Funding Information
- Natural Sciences and Engineering Research Council of Canada (RGPIN-2018-04116)
- Canada Research Chairs (950-232105)
This publication has 179 references indexed in Scilit:
- Essential Role of the Zinc Transporter ZIP9/SLC39A9 in Regulating the Activations of Akt and Erk in B-Cell Receptor Signaling Pathway in DT40 CellsPLOS ONE, 2013
- Endocrine-Disrupting Chemicals: Associated Disorders and Mechanisms of ActionJournal of Environmental and Public Health, 2012
- Induced sex reversal using an aromatase inhibitor, Fadrozole, in Atlantic halibut (Hippoglossus hippoglossus L.)Aquaculture, 2011
- Maternal transfer and transcriptional onset of immune genes during ontogenesis in Atlantic codDevelopmental & Comparative Immunology, 2009
- Neuroendocrine interactions in the immune systemCellular Immunology, 2008
- The fate of the duplicated androgen receptor in fishes: a late neofunctionalization event?BMC Evolutionary Biology, 2008
- Nonylphenol modulates expression of androgen receptor and estrogen receptor genes differently in gender types of the hermaphroditic fish Rivulus marmoratusBiochemical and Biophysical Research Communications, 2006
- Neural regulation of innate immunity: a coordinated nonspecific host response to pathogensNature Reviews Immunology, 2006
- Alternative male reproductive tactics and the immunocompetence handicap in the Azorean rock-pool blenny, Parablennius parvicornisProceedings Of The Royal Society B-Biological Sciences, 2006
- Stress induced elevation of plasma cortisol in adult female coho salmon (Oncorhynchus kisutch), is reflected in egg cortisol content, but does not appear to affect early developmentAquaculture, 1997