The Relationship between Caffeine and Coffee Consumption and Exfoliation Glaucoma or Glaucoma Suspect: A Prospective Study in Two Cohorts
- 1 September 2012
- journal article
- research article
- Published by Association for Research in Vision and Ophthalmology (ARVO) in Investigative Ophthalmology & Visual Science
- Vol. 53 (10), 6427-33
- https://doi.org/10.1167/iovs.12-10085
Abstract
We examined the association between caffeine and caffeinated beverage consumption in relation to the risk of exfoliation glaucoma or exfoliation glaucoma suspect (EG/EGS). We followed 78,977 women from the Nurses' Health Study (NHS) and 41,202 men from the Health Professionals Follow-up Study (HPFS) who were at least 40 years of age, did not have glaucoma, and reported undergoing eye examinations from 1980 (NHS) or 1986 (HPFS) to 2008. Information on consumption of caffeine-containing beverages and potential confounders were repeatedly ascertained in validated follow-up questionnaires. Confirmation with medical record review revealed 360 incident EG/EGS cases. Multivariate rate ratios (RRs) for EG/EGS were calculated in each cohort and then pooled using meta-analytic techniques. Compared with participants whose cumulatively updated total caffeine consumption was <125 mg/day, participants who consumed ≥ 500 mg/day had a trend toward increased risk of EG/EGS that was not statistically significant (RR = 1.43; 95% confidence interval [CI], 0.98-2.08); P trend = 0.06). Compared to abstainers, those who drank ≥ 3 cups of caffeinated coffee daily were at increased risk of EG/EGS (RR = 1.66; 95% CI, 1.09-2.54; P trend = 0.02). These results were not materially altered after adjustment for total fluid intake. Associations were stronger among women with a family history of glaucoma (P interaction = 0.06 for coffee; P interaction = 0.03 for caffeine). We did not find associations with consumption of other caffeinated products (caffeinated soda, caffeinated tea, decaffeinated coffee or chocolate) and risk of EG/EGS (P trend ≥ 0.31). We observed a positive association between heavier coffee consumption with risk of EG/EGS in this large prospective study.This publication has 52 references indexed in Scilit:
- Prevalence of high-risk alleles in theLOXL1gene and its association with pseudoexfoliation syndrome and exfoliation glaucoma in a Latin American populationOphthalmic Genetics, 2011
- Major lifestyle determinants of plasma total homocysteine distribution: the Hordaland Homocysteine StudyThe American Journal of Clinical Nutrition, 1998
- Caffeine and the ElderlyDrugs & Aging, 1998
- Association of Pseudoexfoliation Syndrome With Increased Vascular RiskAmerican Journal of Ophthalmology, 1997
- Reproducibility and validity of food intake measurements from a semiquantitative food frequency questionnaireJournal of the American Dietetic Association, 1993
- Reproducibility and Validity of an Expanded Self-Administered Semiquantitative Food Frequency Questionnaire among Male Health ProfessionalsAmerican Journal of Epidemiology, 1992
- Effects of caffeinated coffee on intraocular pressureApplied Nursing Research, 1991
- Food-Based Validation of a Dietary Questionnaire: The Effects of Week-to-Week Variation in Food ConsumptionInternational Journal of Epidemiology, 1989
- The Effect of Caffeine on Intraocuular Pressure in Glaucoma PatentsOphthalmology, 1989
- Meta-analysis in clinical trialsControlled Clinical Trials, 1986