An Update on Antitumor Activity of Naturally Occurring Chalcones
Open Access
- 17 April 2013
- journal article
- review article
- Published by Hindawi Limited in Evidence-Based Complementary and Alternative Medicine
- Vol. 2013, 1-22
- https://doi.org/10.1155/2013/815621
Abstract
Chalcones, which have characteristic 1,3-diaryl-2-propen-1-one skeleton, are mainly produced in roots, rhizomes, heartwood, leaves, and seeds of generaAngelica, Sophora, Glycyrrhiza, Humulus, Scutellaria, Parartocarpus, Ficus, Dorstenia, Morus, Artocarpus, and so forth. They have become of interest in the research and development of natural antitumor agents over the past decades due to their broad range of mechanisms including anti-initiation, induction of apoptosis, antiproliferation, antimetastasis, antiangiogenesis, and so forth. This review summarizes the studies on the antitumor activity of naturally occurring chalcones and their underlying mechanisms in detail during the past decades.Keywords
This publication has 119 references indexed in Scilit:
- The role of chalcones in suppression of NF-κB-mediated inflammation and cancerInternational Immunopharmacology, 2011
- Dietary chalcones with chemopreventive and chemotherapeutic potentialGenes & Nutrition, 2011
- Chalcone-based inhibitors against hypoxia-inducible factor 1—Structure activity relationship studiesBioorganic & Medicinal Chemistry Letters, 2011
- Flavokawain B, a kava chalcone, induces apoptosis via up‐regulation of death‐receptor 5 and Bim expression in androgen receptor negative, hormonal refractory prostate cancer cell lines and reduces tumor growthInternational Journal of Cancer, 2010
- Flavokawain B, a novel chalcone from Alpinia pricei Hayata with potent apoptotic activity: Involvement of ROS and GADD153 upstream of mitochondria-dependent apoptosis in HCT116 cellsFree Radical Biology & Medicine, 2010
- Butein Suppresses Constitutive and Inducible Signal Transducer and Activator of Transcription (STAT) 3 Activation and STAT3-Regulated Gene Products through the Induction of a Protein Tyrosine Phosphatase SHP-1Molecular Pharmacology, 2008
- Antileukemia effects of xanthohumol in Bcr/Abl-transformed cells involve nuclear factor-κB and p53 modulationMolecular Cancer Therapeutics, 2008
- Combination of isoliquiritigenin and tumor necrosis factor-related apoptosis-inducing ligand induces apoptosis in colon cancer HT29 cellsEnvironmental Health and Preventive Medicine, 2008
- TRAIL receptor-targeted therapeutics: Resistance mechanisms and strategies to avoid themDrug Resistance Updates, 2008
- Cytotoxic chalcones and antioxidants from the fruits of Syzygium samarangense (Wax Jambu)Food Chemistry, 2008