The influence of tumour cell DNA abnormalities on survival in colorectal cancer
- 1 October 1985
- journal article
- research article
- Published by Oxford University Press (OUP) in British Journal of Surgery
- Vol. 72 (10), 828-830
- https://doi.org/10.1002/bjs.1800721018
Abstract
The cellular DNA content was measured from paraffin-embedded material in 134 colorectal cancers from patients in whom the outcome was known. Seventy-two (55 per cent) were found to contain cells with abnormal DNA (DNA aneuploid). The presence of such a population of cells was not related to pathological stage or histological grade. However, only 14 (19 per cent) patients with DNA aneuploid tumours survived 5 years compared with 27 (43 per cent) of patients with diploid tumours (χ2 = 8·0, P = 0·005). Stepwise logistic analysis showed cellular DNA content to be an important prognostic factor in colorectal cancer, independent of pathological stage and histological grade.Keywords
Funding Information
- Cancer Research Campaign
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