Relevance of vitamins C and E in cutaneous photoprotection
- 1 January 2005
- journal article
- Published by Wiley in Journal of Cosmetic Dermatology
- Vol. 4 (1), 4-9
- https://doi.org/10.1111/j.1473-2165.2005.00151.x
Abstract
Ultraviolet (UV) radiation-induced oxidative stress may result in acute and chronic photodamage. Based on the endogenous antioxidant system, the administration of antioxidants for scavenging reactive oxygen species might be a promising strategy in the prevention of UV-induced skin reactions. The relevance of the most common antioxidants, vitamins E and C, is reviewed focusing on topical and systemic photoprotective effects in animals and humans. Topically applied vitamin C induced significant photoprotective effects at concentrations of at least 10% in animals and humans, whereas a photoprotective effect has not been demonstrated by oral administration even at high doses in humans. Topical vitamin E reduced erythema, sunburn cells, chronic UV-B-induced skin damage, and photocarcinogenesis in the majority of the published studies, whereas only high doses of oral vitamin E may affect the response to UV-B in humans. Combination of vitamins C and E, partly with other photoprotective compounds, did increase the photoprotective effects dramatically compared to monotherapies. This synergistic interplay of several antioxidants should be taken into consideration in future research on cutaneous photoprotection.Keywords
This publication has 39 references indexed in Scilit:
- Photoprotection of UV-Irradiated Human Skin: An Antioxidative Combination of Vitamins E and C, Carotenoids, Selenium and ProanthocyanidinsSkin Pharmacology and Physiology, 2002
- Increased antioxidant potential of combined topical vitamin E and C against lipid peroxidation of eicosapentaenoic acid in pig skin induced by simulated solar radiationInternational Journal of Radiation Biology, 2002
- UVB Photoprotection with Antioxidants: Effects of Oral Therapy with d-α-Tocopherol and Ascorbic Acid on the Minimal Erythema DoseActa Dermato-Venereologica, 2002
- Protective effect against sunburn of combined systemic ascorbic acid (vitamin C) and d-α-tocopherol (vitamin E)Journal of the American Academy of Dermatology, 1998
- Phototoxic lysis of erythrocytes from humans is reduced after oral intake of ascorbic acid and d‐α‐tocopherolPhotodermatology, Photoimmunology & Photomedicine, 1997
- Inhibition of cyclobutane pyrimidine dimer formation in epidermal p53 gene of UV‐irradiated mice by α‐tocopherolNutrition and Cancer, 1997
- Prevention of photocarcinogenesis by dietary vitamin ENutrition and Cancer, 1993
- Topical vitamin e inhibition of immunosuppression and tumorigenesis induced by ultraviolet irradiationNutrition and Cancer, 1991
- The influence of topical and systemic vitamin E on ultraviolet light‐induced skin damage in Hairless MiceNutrition and Cancer, 1991
- Systemic Protection by Antioxidants Against Uvl-Induced ErythemaJournal of Investigative Dermatology, 1978