Long-term clinical outcome and left ventricular lead position in cardiac resynchronization therapy
Open Access
- 6 August 2009
- journal article
- research article
- Published by Oxford University Press (OUP) in EP Europace
- Vol. 11 (9), 1177-1182
- https://doi.org/10.1093/europace/eup202
Abstract
To identify the predictive value of a presumed optimal left ventricular lead positions (LV-Ps) on the long-term clinical outcome in patients with cardiac resynchronization therapy (CRT). Clinical information was collected from patient files in consecutive patients treated with CRT from 1997 to 2007. A presumed optimal LV-Ps were defined as a position between 2 and 5 o'clock in the short-axis circumference and basal or mid-ventricular in the long axis. Symptomatic response was defined as improvement in NYHA class (≥1) and echocardiographic response as improvement in left ventricular ejection fraction of ≥5% absolute. We included 567 patients [median age 66 years, 453 (80%) male]. The LV-Ps were optimal in 334 (59%) patients. The hazard ratio for all-cause mortality with an optimal LV-Ps was unadjusted 0.79 (0.59–1.06) and adjusted 0.99 (0.71–1.40). The odds ratio (OR) for symptomatic response with an optimal LV-Ps was unadjusted 1.13 (0.79–1.64) and adjusted 1.05 (0.67–1.64), and the OR for echocardiographic response was unadjusted 1.60 (1.02–2.49) and adjusted 1.42 (0.88–2.31). A presumed optimal LV-Ps between 2 and 5 o'clock in the short-axis circumference and basal or mid-ventricular in the long axis is not associated with a lower mortality or a better clinical response in patients treated with CRT.Keywords
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