Oligodendrocyte Development and Myelin Biogenesis: Parsing Out the Roles of Glycosphingolipids
- 1 October 2009
- journal article
- review article
- Published by American Physiological Society in Physiology
- Vol. 24 (5), 290-297
- https://doi.org/10.1152/physiol.00016.2009
Abstract
The myelin sheath is an extension of the oligoddendrocyte (OL) plasma membrane enriched in lipids that ensheaths the axons of the central and peripheral nervous system. Here, we review the involvement of glycosphingolipids in myelin/OL functions, including the regulation of OL differentiation, lipid raft-mediated trafficking and signaling, and neuronglia interactions.Keywords
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