Complete Remission of Metastatic Cervical Cancer with the Angiogenesis Inhibitor TNP-470

Abstract

TNP-470 is a new inhibitor of angiogenesis that has shown potent antitumor activity in preclinical studies.^1-4 We performed a phase 1 study of this drug in patients with advanced squamous-cell carcinoma of the uterine cervix.⁵ One of the patients in the study was a 49-year-old woman who had presented in 1992 with stage IIIA, poorly differentiated squamous-cell carcinoma of the cervix. She was treated with a combination of external and intracavitary radiation therapy. The side effects of this treatment included recurrent episodes of small-bowel obstruction, requiring surgical exploration and intestinal resection. Pathological examinations of multiple biopsy specimens from the abdomen did not show a recurrence of the cancer.