8‐Oxabicyclo[3.2.1]oct‐6‐en‐3‐ones: Application to the Asymmetric Synthesis of Polyoxygenated Building Blocks
- 30 March 2004
- journal article
- review article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 43 (15), 1934-1949
- https://doi.org/10.1002/anie.200300622
Abstract
The development and design of reliable and efficient methods for the construction of chiral building blocks are crucial in modern natural product synthesis. 8-Oxabicyclo[3.2.1]oct-6-en-3-ones are readily accessible scaffolds with defined stereochemical features which have been exploited for non-aldol approaches to the preparation of chiral building blocks. Strategies for their enantioselective synthesis, including asymmetric cycloaddition methods, desymmetrization protocols, and “racemic switch operations”, are presented and evaluated.Keywords
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