Biotransformed blueberry juice protects neurons from hydrogen peroxide-induced oxidative stress and mitogen-activated protein kinase pathway alterations
- 12 May 2010
- journal article
- research article
- Published by Cambridge University Press (CUP) in British Journal of Nutrition
- Vol. 104 (5), 656-663
- https://doi.org/10.1017/s0007114510001170
Abstract
A growing body of evidence supports the therapeutic effects of blueberry in neurodegenerative disorders. Biotransformation of blueberry juice by Serratia vaccinii bacteria increases its phenolic content and antioxidant activity. In neuronal cell culture, biotransformed blueberry juice (BJ) significantly increased the activity of antioxidant enzymes, namely catalase and superoxide dismutase. Moreover, BJ protected neurons against H2O2-induced cell death in a dose-dependent manner. This associated with the upregulation of mitogen-activated protein kinase (MAPK) family enzymes p38 and c-Jun N-terminal kinase (JNK) activation, as well as with the protection of extracellular signal-regulated kinase (ERK1/2) and MAPK/ERK kinase (MEK1/2) activity loss induced by H2O2. The present studies demonstrate that BJ can protect neurons against oxidative stress possibly by increasing antioxidant enzyme activities and activating p38- and JNK-dependent survival pathways while blocking MEK1/2- and ERK1/2-mediated cell death. Thus, BJ may represent a novel approach to prevent and to treat neurodegenerative disorders, and it may represent a source of novel therapeutic agents against these diseases.Keywords
This publication has 50 references indexed in Scilit:
- Antiobesity and antidiabetic effects of biotransformed blueberry juice in KKAy miceInternational Journal of Obesity, 2009
- Clioquinol inhibits peroxide-mediated toxicity through up-regulation of phosphoinositol-3-kinase and inhibition of p53 activityThe International Journal of Biochemistry & Cell Biology, 2008
- The Dual Functions of Thiol-Based Peroxidases in H2O2Scavenging and SignalingAntioxidants and Redox Signaling, 2008
- Implication of p38 mitogen-activated protein kinase isoforms (α, β, γ and δ) in CD4+ T-cell infection with human immunodeficiency virus type IJournal of General Virology, 2008
- MAPK regulate p53-dependent cell death induced by benzo[a]pyrene: Involvement of p53 phosphorylation and acetylationToxicology, 2008
- Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?Archives of Biochemistry and Biophysics, 2008
- Oxidative stress in neurodegeneration and available means of protectionFrontiers in Bioscience-Landmark, 2008
- Dietary polyphenols: Good, bad, or indifferent for your health?Cardiovascular Research, 2007
- ANTIOXIDANT ACTIVITY OF FERMENTED BERRY JUICES AND THEIR EFFECTS ON NITRIC OXIDE AND TUMOR NECROSIS FACTOR-ALPHA PRODUCTION IN MACROPHAGES 264.7 GAMMA NO(-) CELL LINEJournal of Food Biochemistry, 2006
- Flavonoids of Inula britannica protect cultured cortical cells from necrotic cell death induced by glutamateFree Radical Biology & Medicine, 2002