On gluconeogenesis of human liver
- 1 December 1976
- journal article
- Published by Springer Science and Business Media LLC in Diabetologia
- Vol. 12 (6), 555-561
- https://doi.org/10.1007/bf01220631
Abstract
In 8 subjects in whom portal vein catheters had been inserted 5–6 days previously during cholecystectomy, arterial and portal concentrations of glucose, lactate, pyruvate, glycerol, alanine, free fatty acids,β-hydroxybutyrate and acetoacetate revealed no significant differences. This provided the basis for the calculation of hepatic balances from arterio-hepatic venous substrate-differences in 17 healthy volunteers. In eight of them metabolic balances were determined during elevated hepatic lactate supply. Kinetics of the substrates throughout the whole test period in 9 controls showed no gross interference from the catheterization or infusion procedure. The elevated hepatic lactate concentration caused a doubling of hepatic glucose output, which could almost entirely be accounted for by a fivefold increase of hepatic lactate uptake. This acceleration of hepatic gluconeogenesis was accompanied by a significant increment of hepatic free fatty acid uptake, whereas hepatic ketone body production did not change. These data seem to support the view that hepatic energy requirements caused by an accelerated gluconeogenesis might be covered from enhanced free fatty acid oxidation.Keywords
This publication has 28 references indexed in Scilit:
- Uptake of individual free fatty acids by skeletal muscle and liver in manJCI Insight, 1972
- Regulation of ketogenesis and clinical aspects of the ketotic stateMetabolism, 1972
- Glucose metabolism during leg exercise in manJCI Insight, 1971
- Splanchnic metabolism of free fatty acids and production of triglycerides of very low density lipoproteins in normotriglyceridemic and hypertriglyceridemic humansJCI Insight, 1970
- Liver and kidney metabolism during prolonged starvationJCI Insight, 1969
- Partition Coefficient of133Xenon between Various Tissues and Blood in VivoScandinavian Journal of Clinical and Laboratory Investigation, 1967
- The regulation of the release of ketone bodies by the liverAdvances in Enzyme Regulation, 1966
- Eine neue Bestimmung der Neutralfette im Blutserum und GewebeJournal of Molecular Medicine, 1966
- The Mechanism of the Fructose Effect on the Ethanol Metabolism of the Human Liver*JCI Insight, 1965
- NET SPLANCHNIC GLUCOSE PRODUCTION IN NORMAL MAN AND IN VARIOUS DISEASE STATES 1JCI Insight, 1950