Studies of the efficacy of a novel intranasal vaccine against feline bordetellosis
- 6 April 2002
- journal article
- research article
- Published by Wiley in Veterinary Record
- Vol. 150 (14), 439-442
- https://doi.org/10.1136/vr.150.14.439
Abstract
A novel intranasal vaccine against disease caused by Bordetella bronchiseptica in cats was tested in a series of three experiments. In the first experiment a vaccinated group and an unvaccinated control group of kittens were challenged by the aerosol route with virulent B bronchiseptica three weeks after they had been vaccinated. The control kittens developed upper respiratory tract signs typical of feline B bronchiseptica infection, including rhinitis, a serous ocular and nasal discharge, fever, sneezing and coughing. The mean (sd) clinical score for the cats in the unvaccinated control group was 19.5 (5.4) compared with 1.53 (1.9) for the vaccinated group. In the second experiment vaccinated kittens were challenged with virulent B bronchiseptica 72 hours after they were vaccinated. Their mean clinical score was 2.76 (2.62) compared with 13.4 (3.33) for the control group. In the final experiment, vaccinated and unvaccinated control cats were challenged after six or 12 months. After six months the mean clinical scores were 13.9 (4.7) for the control group, compared with 1.33 (1.56) for the vaccinated group, and after 12 months the scores were 9.92 (5.79) for the control group compared with 0.92 (0.89) for the vaccinated group.Keywords
This publication has 11 references indexed in Scilit:
- A Study of Feline Upper Respiratory Tract Disease with Reference to Prevalence and Risk Factors for Infection with Feline Calicivirus and Feline HerpesvirusJournal of Feline Medicine and Surgery, 2000
- Bordetella bronchiseptica infection in cats following contact with infected dogsVeterinary Record, 2000
- Prevalence and risk factors for feline Bordetella bronchiseptica infectionVeterinary Record, 1999
- Prevalence of antibodies against bordetella bronchiseptica in cats with a history of respiratory diseaseVeterinary Quarterly, 1997
- Bordetella bronchiseptica infections in catsJournal of the American Animal Hospital Association, 1996
- Studies on natural transmission of Bordetella bronchiseptica in catsVeterinary Microbiology, 1996
- Seroprevalence and isolation rate of Bordetella bronchiseptica in cats in the UKPublished by Wiley ,1994
- Feline bordetellosis: challenge and vaccine studiesVeterinary Record, 1993
- Isolation of B bronchiseptica from kittens with pneumonia in a breeding catteryPublished by Wiley ,1991
- The pathogenesis of turbinate atrophy in pigs caused by Bordetella bronchisepticaVeterinary Microbiology, 1988